Evidence map›Paper›PMID 30714156›Full record

ArticleThe Journal of physiology2019

β-adrenergic-mediated dynamic augmentation of sarcolemmal Ca

Danica W Ito, Karen I Hannigan, Debapriya Ghosh, Bing Xu, Silvia G Del Villar, Yang K Xiang, Eamonn J Dickson, Manuel F Navedo, Rose E Dixon

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. CaThe Journal of physiology · 2026
    Article
  5. Nanoscale CabioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Amyloid β alters vascular CaThe Journal of physiology · 2025
    Article
  8. Review
  9. Article
  10. Bend it like BIN1: how a membrane-curving adaptor protein shapes cardiac physiology.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  11. 14-3-3 promotes sarcolemmal expression of cardiac CaProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Review
  13. Article
  14. CaCommunications biology · 2024
    Article
  15. Article
  16. Article
  17. The Dysfunction of CaInternational journal of molecular sciences · 2023
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Danica W ItoDepartment of Physiology & Membrane Biology, University of California Davis, Davis, CA, USA.
Karen I HanniganDepartment of Physiology & Membrane Biology, University of California Davis, Davis, CA, USA.
Debapriya GhoshDepartment of Pharmacology, University of California Davis, Davis, CA, USA.
Bing XuDepartment of Pharmacology, University of California Davis, Davis, CA, USA.
Silvia G Del VillarDepartment of Physiology & Membrane Biology, University of California Davis, Davis, CA, USA.
Yang K XiangDepartment of Pharmacology, University of California Davis, Davis, CA, USA.ORCID 0000-0003-1786-9143
Eamonn J DicksonDepartment of Physiology & Membrane Biology, University of California Davis, Davis, CA, USA.ORCID 0000-0001-8619-7630
Manuel F NavedoDepartment of Pharmacology, University of California Davis, Davis, CA, USA.ORCID 0000-0001-6864-6594
Rose E DixonDepartment of Physiology & Membrane Biology, University of California Davis, Davis, CA, USA.ORCID 0000-0003-0655-690X
University of California, Davis · USVA Northern California Health Care System · US

Funding

Training Program In Basic & Translational Cardiovascular ScienceT32HL086350 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, David A. Liem · 2008 to 2026
$7.1M
Coupling of Vascular Cav1.2 Channels In Health & DiseaseR01HL121059 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAVEDO, MANUEL F · 2015 to 2024
$4.5M
Calcium Sparklets-Induced Vascular Dysfunction During DiabetesR01HL098200 · NHLBI · UNIVERSITY OF WASHINGTON · PI NAVEDO, MANUEL F · 2010 to 2019
$3.5M
Membrane contact sites regulate cellular excitabilityR01GM127513 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DICKSON, EAMONN JAMES · 2019 to 2023
$1.6M
Molecular mechanisms of Insulin resistance under chronic stressI01BX002900 · VA · VA NORTHERN CALIFORNIA HEALTH CARE SYS · PI XIANG, YANG K · 2016 to 2021
–
American Heart Association-American Stroke Association 15SDG25560035BLRD VA I01 BX002900NHLBI NIH HHS R01 HL098200NHLBI NIH HHS R01 HL121059NHLBI NIH HHS T32 HL086350NIGMS NIH HHS R01 GM127513
6 · The paper itself

Abstract

key pointsPrevailing dogma holds that activation of the β-adrenergic receptor/cAMP/protein kinase A signalling pathway leads to enhanced L-type Ca ABSTRACT: Voltage-dependent L-type Ca

Indexed as

Adrenergic beta-AgonistsAnimalsCalcium Channels, L-TypeCell LineFemaleHeart VentriclesHumansIsoproterenolMaleMice, Inbred C57BLMyocytes, CardiacReceptors, Adrenergic, betaSarcolemmaAdrenergic beta-AgonistsCACNA1C protein, mouseCalcium Channels, L-TypeIsoproterenolReceptors, Adrenergic, betacoupled gatingL-type calcium channelsβ-adrenergic receptors

Identifiers

PMID30714156
PMCPMC6462464
OpenAlexW2914052533

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.