Evidence map›Paper›PMID 30714026›Full record

ArticleJournal of the American College of Clinical Pharmacy : JACCP2018

Pharmacist-Led, Technology-Assisted Study to Improve Medication Safety, Cardiovascular Risk Factor Control, and Racial Disparities in Kidney Transplant Recipients.

David J Taber, Mulugeta Gebregziabher, Aurora Posadas, Caitlin Schaffner, Leonard E Egede, Prabhakar K Baliga

Registry-linked trialAbstract read
In one paragraph

Article in Journal of the American College of Clinical Pharmacy : JACCP, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02763943 (Improving Medication Safety and Cardiovascular Risk Factor Control in Kidney Transplant Recipients), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02763943 nacompletednot on this map

Improving Medication Safety and Cardiovascular Risk Factor Control in Kidney Transplant Recipients

TypeinterventionalSponsorMedical University of South CarolinaRan2016 to 2018Enrolled60ConditionsCardiovascular Diseases, Diabetes Mellitus, Medication AdherenceArmsPharmacist-led, technology enabled education intervention
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Results of a multicenter cluster-randomized controlled clinical trial testing the effectiveness of a bioinformatics-enabled pharmacist intervention in transplant recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David J TaberDivision of Transplant Surgery, College of Medicine, Medical University of South Carolina, Charleston, SC.
Mulugeta GebregziabherDepartment of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC.
Aurora PosadasDivision of Transplant Nephrology, College of Medicine, Medical University of South Carolina, Charleston, SC.
Caitlin SchaffnerDivision of Transplant Surgery, College of Medicine, Medical University of South Carolina, Charleston, SC.
Leonard E EgedeDivision of General Internal Medicine, Medical College of Wisconsin, Milwaukee, WI.
Prabhakar K BaligaDepartment of Surgery, College of Medicine, Medical University of South Carolina, Charleston, SC.

Funding

Impact of Cardiovascular Risk Control on Racial Disparities in Kidney TransplantK23DK099440 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TABER, DAVID J. · 2014 to 2017
$715k
NIDDK NIH HHS K23 DK099440
6 · The paper itself

Abstract

introductionHealth disparities in African-American (AA) kidney transplant recipients compared with non-AA recipients are well established. Cardiovascular disease (CVD) risk control is a significant mediator of this disparity.

objectiveTo assess the efficacy of improved medication safety, CVD risk control, and racial disparities in kidney transplant recipients.

methodsProspective, pharmacist-led, technology-aided, 6-month interventional clinical trial. A total of 60 kidney recipients with diabetes and hypertension were enrolled. Patients had to be at least one-year post transplant with stable graft function. Primary outcome measured included hypertension, diabetes, and lipid control using intent-to-treat analyses, with differences assessed between AA and non-AA recipients.

resultsThe participants mean age was 59 years, with 42% being female and 68% being AA. Overall, patients demonstrated improvements in blood pressure <140/90 mmHg (baseline 50% vs. end of study 68%, p=0.054) and hemoglobin A1c <7% (baseline 33% vs. end of study 47%, p=0.061). AAs demonstrated a significant reduction from baseline in systolic blood pressure (-0.86 mmHg per month, p=0.026), which was not evident in non-AAs (-0.13 mmHg per month, p=0.865). Mean HgbA1c decreased from baseline in the overall group (-0.12% per month, p=0.003), which was similar within AAs (-0.11% per month, p=0.004) and non-AAs (-0.14% per month, p=0.029). There were no changes in low-density lipoproteins, triglycerides, or high-density lipoproteins over the course of the study. Medication errors were significantly reduced and self-reported medication adherence significantly improved over the course of the study.

conclusionThese results demonstrate the potential efficacy of a pharmacist-led, technology-aided, educational intervention in improving medication safety, diabetes, and hypertension and reducing racial disparities in AA kidney transplant recipients. (ClinicalTrials.gov NCT02763943).

Indexed as

African Americanscardiovascular diseaseshealthcare disparitieshypertensionkidney transplantationmedication errors

Identifiers

PMID30714026
PMCPMC6350824

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.