ArticleChem2019
Charge Transfer between [4Fe4S] Proteins and DNA Is Unidirectional: Implications for Biomolecular Signaling.
Article in Chem, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Probing the Role of Accessory FeS Clusters in Putative Sensory Group D [FeFe] Hydrogenase: Influence of the C-Terminal [4Fe-4S] Cluster on the Reactivity ofBiochemistry · 2026Article
- FeSBCP analogue from cyanobacteria: insights from in vitro and in silico studies.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025Article
- Unveiling the charge transport blockade in the D2 branch of the photosystem II reaction center.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Effects of environmental noise on quantum charge diffusion in DNA sequences.Scientific reports · 2025Article
- Article
- Keto-Adamantane-Based Macrocycle Crystalline Supramolecular Assemblies Showing Selective Vapochromism to Tetrahydrofuran.Molecules (Basel, Switzerland) · 2024Article
- Long-Range Conductivity in Proteins Mediated by Aromatic Residues.ACS physical chemistry Au · 2023Article
- Modification of the 4Fe-4S Cluster Charge Transport Pathway Alters RNA Synthesis by Yeast DNA Primase.Biochemistry · 2022Article
- Multiple hops move electrons from bacteria to rocks.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Why Do Most Aromatics Fail to Support Hole Hopping in the CytochromeThe journal of physical chemistry. B · 2021Article
- Oxalate decarboxylase uses electron hole hopping for catalysis.The Journal of biological chemistry · 2021Article
- How the Donor/Acceptor Spin States Affect the Electronic Couplings in Molecular Charge-Transfer Processes?Journal of chemical theory and computation · 2021Article
- Correlation between Charge Transport and Base Excision Repair in the MutY-DNA Glycosylase.The journal of physical chemistry. B · 2021Article
- Implications of Membrane Binding by the Fe-S Cluster-Containing N-Terminal Domain in theFrontiers in genetics · 2021Article
- Mutation effects on charge transport through the p58c iron-sulfur protein.Chemical science · 2020Article
- Revisiting the Hole Size in Double Helical DNA with Localized Orbital Scaling Corrections.The journal of physical chemistry. B · 2020Article
- Formation of a Copper(II)-Tyrosyl Complex at the Active Site of Lytic Polysaccharide Monooxygenases Following Oxidation by HJournal of the American Chemical Society · 2019Article
- 2'-Deoxy-2'-fluoro-arabinonucleic acid: a valid alternative to DNA for biotechnological applications using charge transport.Physical chemistry chemical physics : PCCP · 2019Article
- Mapping hole hopping escape routes in proteins.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Why Are DNA and Protein Electron Transfer So Different?Annual review of physical chemistry · 2019Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Recent experiments suggest that DNA-mediated charge transport might enable signaling between the [4Fe4S] clusters in the C-terminal domains of human DNA primase and polymerase α, as well as the signaling between other replication and repair high-potential [4Fe4S] proteins. Our theoretical study demonstrates that the redox signaling cannot be accomplished exclusively by DNA-mediated charge transport because part of the charge transfer chain has an unfavorable free energy profile. We show that hole or excess electron transfer between a [4Fe4S] cluster and a nucleic acid duplex through a protein medium can occur within microseconds in one direction, while it is kinetically hindered in the opposite direction. We present a set of signaling mechanisms that may occur with the assistance of oxidants or reductants, using the allowed charge transfer processes. These mechanisms would enable the coordinated action of [4Fe4S] proteins on DNA, engaging the [4Fe4S] oxidation state dependence of the protein-DNA binding affinity.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.