Evidence map›Paper›PMID 30713803›Full record

ArticleOncoimmunology

Tumor-infiltrating T cells and PD-L1 expression in childhood malignant extracranial germ-cell tumors.

Renata Boldrini, Maria Debora De Pasquale, Ombretta Melaiu, Marco Chierici, Giuseppe Jurman, Maria Chiara Benedetti, Nunzio C Salfi, Aurora Castellano, Paola Collini, Cesare Furlanello and 4 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

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  8. Biomarkers for Salvage Therapy in Testicular Germ Cell Tumors.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Renata BoldriniDepartment of Pathology, IRCCS, Ospedale Pediatrico Bambino Gesù, Rome, Italy.
Maria Debora De PasqualeDepartment of Oncohaematology, IRCCS, Ospedale Pediatrico Bambino Gesù, Rome, Italy.
Ombretta MelaiuDepartment of Oncohaematology, IRCCS, Ospedale Pediatrico Bambino Gesù, Rome, Italy.
Marco ChiericiFondazione Bruno Kessler, Trento, Italy.
Giuseppe JurmanFondazione Bruno Kessler, Trento, Italy.
Maria Chiara BenedettiDepartment of Pathology, IRCCS, Ospedale Pediatrico Bambino Gesù, Rome, Italy.
Nunzio C SalfiDepartment of Pathology, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Aurora CastellanoDepartment of Oncohaematology, IRCCS, Ospedale Pediatrico Bambino Gesù, Rome, Italy.
Paola ColliniDepartment of Diagnostic Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Cesare FurlanelloFondazione Bruno Kessler, Trento, Italy.
Vito PistoiaImmunology Research Area IRCCS, Ospedale Pediatrico Bambino Gesù, Rome, Italy.
Loredana CifaldiDepartment of Oncohaematology, IRCCS, Ospedale Pediatrico Bambino Gesù, Rome, Italy.ORCID 0000-0001-5014-430X
Monica TerenzianiDepartment of Pediatric Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Doriana FruciDepartment of Oncohaematology, IRCCS, Ospedale Pediatrico Bambino Gesù, Rome, Italy.ORCID 0000-0003-3388-7296
Bambino Gesù Children's Hospital · ITFondazione Bruno Kessler · ITFondazione IRCCS Istituto Nazionale dei Tumori · ITIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although pediatric malignant extracranial germ-cell tumors (meGCTs) are among the most chemosensitive solid tumors, a group of patients relapse and die of disease. To identify new markers predicting clinical outcome, we examined the prognostic relevance of tumor-infiltrating T lymphocytes (TILs) and the expression of PD-1 and PD-L1 in a cohort of pediatric meGCTs by

Indexed as

effector T cellsimmunohistochemistrymalignant extracranial germ-cell tumorPD-1PD-L1pediatric cancerregulatory T cellsTumor microenvironment

Identifiers

PMID30713803
PMCPMC6343784
OpenAlexW2903896579

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.