Evidence map›Paper›PMID 30713756›Full record

ArticleInterventional medicine & applied science2018

A novel hydrogel scaffold for periodontal ligament stem cells.

Krisztina Nagy, Orsolya Láng, Júlia Láng, Katalin Perczel-Kovách, Szabolcs Gyulai-Gaál, Kristóf Kádár, László Kőhidai, Gábor Varga

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Article in Interventional medicine & applied science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Extracellular Vesicles in Facial Aesthetics: A Review.International journal of molecular sciences · 2022
    Review
  8. Polymeric Hydrogels for In Vitro 3D Ovarian Cancer Modeling.International journal of molecular sciences · 2022
    Review
  9. Article
  10. Biomaterials and biotechnology for periodontal tissue regeneration: Recent advances and perspectives.Journal of dental research, dental clinics, dental prospects · 2022
    Review
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Krisztina NagyDepartment of Oral Biology, Semmelweis University, Budapest, Hungary.
Orsolya LángDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
Júlia LángDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
Katalin Perczel-KováchDepartment of Oral Biology, Semmelweis University, Budapest, Hungary.
Szabolcs Gyulai-GaálDepartment of Oral Diagnostics, Semmelweis University, Budapest, Hungary.
Kristóf KádárDepartment of Oral Biology, Semmelweis University, Budapest, Hungary.
László KőhidaiDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
Gábor VargaDepartment of Oral Biology, Semmelweis University, Budapest, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontal ligament stem cells (PDLSCs) possess extensive regeneration potential. However, their therapeutic application demands a scaffold with appropriate properties. HydroMatrix (HydM) is a novel injectable peptide nanofiber hydrogel developed recently for cell culture. Our aim was to test whether HydM would be a suitable scaffold for proliferation and osteogenic differentiation of PDLSCs. PDLSCs were seeded on non-coated or HydM-coated surfaces. Both real-time impedance analysis and cell viability assay documented cell growth on HydM. PDLSCs showed healthy, fibroblast-like morphology on the hydrogel. After a 3-week-long culture in osteogenic medium, mineralization was much more intense in HydM cultures compared to control. Alkaline phosphatase activity of the cells grown on the gels reached the non-coated control levels. Our data provided evidence that PDLSCs can adhere, survive, migrate, and proliferate on HydM and this gel also supports their osteogenic differentiation. We first applied impedimetry for dental stem cells cultured on a scaffold. HydM is ideal for

Indexed as

cell proliferationHydroMatriximpedimetryosteogenic differentiationperiodontal ligamentstem cell

Identifiers

PMID30713756
PMCPMC6343580

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.