ArticleRMD open2019
Peripheral disease contributes significantly to the level of disease activity in axial spondyloarthritis.
Article in RMD open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 64 citations in OpenAlex.
- Influence of initial axial involvement on the phenotypic evolution of axial spondyloarthritis: 10-year data from the DESIR cohort.RMD open · 2026Article
- [Axial spondyloarthritis].Innere Medizin (Heidelberg, Germany) · 2026Review
- A comprehensive evaluation of radiographic trochanteric enthesitis in axial spondyloarthritis : Prevalence, disease activity, and functional impairments.Zeitschrift fur Rheumatologie · 2025Observational
- Clinical characteristics of peripheral joint disease in axial and peripheral spondyloarthritis: findings from a multicentre cross-sectional study.Rheumatology international · 2025Article
- Diagnostic delay in patients from the International Map of Axial Spondyloarthritis: geographic, sociodemographic and disease-related factors.Rheumatology (Oxford, England) · 2025Article
- Observational
- Radiographic entheseal lesions of the pelvic region are more prevalent in radiographic axSpA than in age- and sex-matched controls and are associated with more severe spinal disease.Clinical rheumatology · 2025Article
- Real-world use of ixekizumab for axial spondyloarthritis treatment in Spain (ESPADA study).Frontiers in medicine · 2025Article
- Decoding the inflammatory-osteogenic axis in ankylosing spondylitis: mechanisms, dysregulation, and emerging therapeutic interventions.Frontiers in immunology · 2025Review
- Difficult-to-Treat Spondyloarthritis in Morocco: A Real-World Study.Mediterranean journal of rheumatology · 2024Article
- Difficult-to-treat axial spondyloarthritis patients.Archives of rheumatology · 2024Article
- Different Therapeutic Response to Anti-TNF Drugs in Patients with Axial Spondyloarthritis Depending on Their Clinical Profile: An Unsupervised Cluster Analysis.Journal of clinical medicine · 2024Article
- A mixed methods study to uncover impediments to accurate diagnosis of nonradiographic axial spondyloarthritis in the USA.Clinical rheumatology · 2023Article
- Extra-musculoskeletal manifestations driving the therapeutic decision-making in patients with Spondyloarthritis: a 12-month follow-up prospective cohort study.Advances in rheumatology (London, England) · 2023Article
- Editorial: Recent advances in pediatric inflammatory diseases.Frontiers in pediatrics · 2023Article
- Peripheral spondyloarthritis and psoriatic arthritisRMD open · 2022Review
- Predictors of not Achieving Remission or Low Disease Activity in Axial Spondyloarthritis Patients from Middle Eastern Countries: A Prospective, Multicenter, Real-world Study.Oman medical journal · 2022Article
- An Italian Disease-Based Registry of Axial and Peripheral Spondyloarthritis: The SIRENA Study.Frontiers in medicine · 2021Article
- Revisiting the gut-joint axis: links between gut inflammation and spondyloarthritis.Nature reviews. Rheumatology · 2020Review
- Characterization of Patients With Axial Spondyloarthritis by Enthesitis Presence: Data from the Corrona Psoriatic Arthritis/Spondyloarthritis Registry.ACR open rheumatology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Spondyloarthritis (SpA) can encompass axial, peripheral and extra-articular disease manifestations. Patients are classified as axial or peripheral SpA depending on the presence or absence of current back pain, independently of the other disease manifestations. Therefore, we aimed to assess the percentage of patients with axial SpA with peripheral disease and how this peripheral disease contributes to the overall disease activity. Methods: Prevalence and disease activity of peripheral disease manifestations were assessed in a real-life observational cohort of 314 patients with the clinical diagnosis of SpA and fulfilling the Assessment of SpondyloArthritis international Society (ASAS) criteria. Results: Of the 314 patients fulfilling the ASAS criteria, 230 fulfilled the axial and 84 the peripheral SpA criteria. Of the 230 patients with axial SpA, 49% had purely axial disease without peripheral disease manifestations whereas 51% had combined axial (back pain) and peripheral (arthritis, enthesitis and/or dactylitis) disease. The latter group had the highest disease activity in comparison with pure axial SpA as well as with peripheral SpA. Conclusion: Half of the patients classified as axial SpA according to the ASAS criteria also have peripheral disease manifestations such as arthritis, enthesitis and/or dactylitis. These peripheral disease manifestations contribute significantly to overall disease activity.
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