Evidence map›Paper›PMID 30713718›Full record

ArticleRMD open2019

Novel protective role for MAP kinase phosphatase 2 in inflammatory arthritis.

Juliane Schroeder, Kirsty Ross, Kathryn McIntosh, Shilan Jabber, Stuart Woods, Jenny Crowe, Janet Patterson Kane, James Alexander, Catherine Lawrence, Robin Plevin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RMD open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Juliane SchroederInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland.
Kirsty RossPure and Applied Chemistry, Technology Innovation Centre, University of Strathclyde, Glasgow, Scotland.
Kathryn McIntoshStrathclyde Institute for Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland.ORCID 0000-0003-0222-3585
Shilan JabberStrathclyde Institute for Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland.
Stuart WoodsStrathclyde Institute for Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland.
Jenny CroweInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland.
Janet Patterson KaneFlagship Biosciences Inc, Massey University, Denver, Colorado, USA.
James AlexanderStrathclyde Institute for Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland.
Catherine LawrenceStrathclyde Institute for Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland.
Robin PlevinStrathclyde Institute for Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland.
University of Strathclyde · GBInstitute of Infection and Immunity · CA

Funding

Wellcome TrustWellcome Trust WT089273MA
6 · The paper itself

Abstract

Objectives: We have previously shown mitogen-activated protein kinase phosphatase 2 (MKP-2) to be a key regulator of proinflammatory cytokines in macrophages. In the study presented here, we investigated the role of MKP-2 in inflammatory arthritis with a particular focus on neutrophils. Methods: To achieve this, we subjected MKP-2 deficient and wild type mice to collagen antibody induced arthritis, an innate model of arthritis, and determined disease pathology. To further our investigation, we depleted neutrophils in a prophylactic and therapeutic fashion. Last, we used chemotaxis assays to analyse the impact of MKP-2 deletion on neutrophil migration. Results: MKP-2 Conclusions: This is the first study to show a protective role for MKP-2 in inflammatory arthritis.

Indexed as

AnimalsArthritisArthritis, ExperimentalCytokinesDisease Models, AnimalDisease SusceptibilityGenetic Association StudiesInflammation MediatorsMaleMiceMice, KnockoutOptical ImagingProtein Tyrosine PhosphatasesCytokinesDusp4 protein, mouseInflammation MediatorsProtein Tyrosine Phosphatasesarthritischemokinesinflammation

Identifiers

PMID30713718
PMCPMC6340532
OpenAlexW2910407229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.