Evidence map›Paper›PMID 30713640›Full record

ArticleChemical science2019

A cell membrane-anchored fluorescent probe for monitoring carbon monoxide release from living cells.

Shuai Xu, Hong-Wen Liu, Xia Yin, Lin Yuan, Shuang-Yan Huan, Xiao-Bing Zhang

Abstract read
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Review
  3. Propofol Induces the Expression of Nrf2 and HO-1 inTropical medicine and infectious disease · 2023
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. A de novo strategy to develop NIR precipitating fluorochrome for long-term in situ cell membrane bioimaging.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shuai XuMolecular Science and Biomedicine Laboratory , State Key Laboratory of Chemo/Biosensing and Chemometrics , College of Chemistry and Chemical Engineering , Collaborative Innovation Center for Chemistry and Molecular Medicine , Hunan University , Changsha , 410082 , P. R. China . Email: syhuan@hnu.edu.cn ; Email: xbzhang@hnu.edu.cn.
Hong-Wen LiuMolecular Science and Biomedicine Laboratory , State Key Laboratory of Chemo/Biosensing and Chemometrics , College of Chemistry and Chemical Engineering , Collaborative Innovation Center for Chemistry and Molecular Medicine , Hunan University , Changsha , 410082 , P. R. China . Email: syhuan@hnu.edu.cn ; Email: xbzhang@hnu.edu.cn.ORCID 0000-0001-8757-1620
Xia YinMolecular Science and Biomedicine Laboratory , State Key Laboratory of Chemo/Biosensing and Chemometrics , College of Chemistry and Chemical Engineering , Collaborative Innovation Center for Chemistry and Molecular Medicine , Hunan University , Changsha , 410082 , P. R. China . Email: syhuan@hnu.edu.cn ; Email: xbzhang@hnu.edu.cn.
Lin YuanMolecular Science and Biomedicine Laboratory , State Key Laboratory of Chemo/Biosensing and Chemometrics , College of Chemistry and Chemical Engineering , Collaborative Innovation Center for Chemistry and Molecular Medicine , Hunan University , Changsha , 410082 , P. R. China . Email: syhuan@hnu.edu.cn ; Email: xbzhang@hnu.edu.cn.ORCID 0000-0002-1015-5319
Shuang-Yan HuanMolecular Science and Biomedicine Laboratory , State Key Laboratory of Chemo/Biosensing and Chemometrics , College of Chemistry and Chemical Engineering , Collaborative Innovation Center for Chemistry and Molecular Medicine , Hunan University , Changsha , 410082 , P. R. China . Email: syhuan@hnu.edu.cn ; Email: xbzhang@hnu.edu.cn.
Xiao-Bing ZhangMolecular Science and Biomedicine Laboratory , State Key Laboratory of Chemo/Biosensing and Chemometrics , College of Chemistry and Chemical Engineering , Collaborative Innovation Center for Chemistry and Molecular Medicine , Hunan University , Changsha , 410082 , P. R. China . Email: syhuan@hnu.edu.cn ; Email: xbzhang@hnu.edu.cn.ORCID 0000-0002-4010-0028

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbon monoxide (CO) acts as an important gasotransmitter in delivering intramolecular and intermolecular signals to regulate a variety of physiological processes. This lipid-soluble gas can freely pass through the cell membrane and then diffuse to adjacent cells acting as a messenger. Although many fluorescent probes have been reported to detect intracellular CO, it is still a challenge to visualize the release behavior of endogenous CO. The main obstacle is the lack of a probe that can anchor onto the cell membrane while having the ability to image CO in real time. In this work, by grafting a polar head onto a long and linear hydrophobic Nile Red molecule, a cell membrane-anchored fluorophore

Identifiers

PMID30713640
PMCPMC6333233

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.