ArticleChemical science2019
Molecular design of near-infrared fluorescent Pdots for tumor targeting: aggregation-induced emission
Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Simulation-guided design of a 3D flow focusing chip for the uniform production of polymer dots.RSC advances · 2026Article
- Asymmetric Xanthene with Noncovalent Conformation Locks to Attain High Fluorescence >1500 nm.Journal of the American Chemical Society · 2026Article
- Integrating Ultrabright Polymer Dots and Stereo NIR-II Imager for Assessing Anti-Angiogenic Drugs in Oral Cancer Model.Journal of cellular and molecular medicine · 2025Article
- Aggregation-induced emission luminescence for angiography and atherosclerotic diagnosis.iScience · 2024Review
- Accessing the electronic structure of liquid crystalline semiconductors with bottom-up electronic coarse-graining.Chemical science · 2024Article
- Semiconducting polymer dots for multifunctional integrated nanomedicine carriers.Materials today. Bio · 2024Review
- Albumin-seeking dyes with adjustable assembliesTheranostics · 2024Article
- Critical assessment of selenourea as an efficient small molecule fluorescence quenching probe to monitor protein dynamics.Chemical science · 2023Article
- Brightness of fluorescent organic nanomaterials.Chemical Society reviews · 2023Review
- BODIPY-based near-infrared semiconducting polymer dot for selective yellow laser-excited cell imaging.RSC advances · 2023Article
- Design, Synthesis, and Biomedical Application of Multifunctional Fluorescent Polymer Nanomaterials.Molecules (Basel, Switzerland) · 2023Review
- Recent Advances of NIR-II Emissive Semiconducting Polymer Dots for In Vivo Tumor Fluorescence Imaging and Theranostics.Biosensors · 2022Review
- Visualization of Mitochondria During Embryogenesis in Zebrafish by Aggregation-Induced Emission Molecules.Molecular imaging and biology · 2022Article
- Surfactant-chaperoned donor-acceptor-donor NIR-II dye strategy efficiently circumvents intermolecular aggregation to afford enhanced bioimaging contrast.Chemical science · 2022Article
- The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates.ACS nanoscience Au · 2022Review
- The long-circulating effect of pegylated nanoparticles revisitedActa pharmaceutica Sinica. B · 2022Article
- Deep-red fluorescence from isolated dimers: a highly bright excimer and imagingChemical science · 2020Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Semiconducting polymer dots (Pdots) have recently emerged as a new type of ultrabright fluorescent probe that has been proved to be very useful for biomedical imaging. However, Pdots often suffer from serious fluorescence aggregation-caused quenching (ACQ) especially for near-infrared (NIR) fluorescent Pdots. This article compared two strategies to overcome the ACQ effect in near-infrared emissive Pdot systems: aggregation-induced emission (AIE) and anti-aggregation-caused quenching (anti-ACQ). The results show that the anti-ACQ platform outperforms the AIE system. The fluorescence quantum yield of anti-ACQ-based Pdots can be over 50% and the average per-particle brightness of the Pdots is about 5 times higher than that of the commercially available quantum dots. To help understand why the monomer conformations could greatly affect the optical properties of Pdots, molecular dynamics simulations were performed for the first time in such complicated Pdot systems. To demonstrate applications for
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Registered trials
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