Evidence map›Paper›PMID 30713537›Full record

ArticleFrontiers in immunology2018

IgG Fc Glycosylation Patterns of Preterm Infants Differ With Gestational Age.

Nele Twisselmann, Yannic C Bartsch, Julia Pagel, Christian Wieg, Annika Hartz, Marc Ehlers, Christoph Härtel

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. Immune development in early life.Nature immunology · 2026
    Review
  2. Article
  3. Endothelial cells sialylate IgG within the FcRn-mediated recycling pathway.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Role of Antibody Glycosylation in Health, Disease, and Therapy.Handbook of experimental pharmacology · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Sweet Rules: Linking Glycosylation to Antibody Function.Experientia supplementum (2012) · 2021
    Review
  18. Maternal Immunization: Nature Meets Nurture.Frontiers in microbiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nele TwisselmannDepartment of Pediatrics, University of Lübeck and University Medical Center Schleswig-Holstein, Lübeck, Germany.
Yannic C BartschLaboratories of Immunology and Antibody Glycan Analysis, Institute for Nutrition Medicine, University of Lübeck and University Medical Center Schleswig-Holstein, Lübeck, Germany.
Julia PagelDepartment of Pediatrics, University of Lübeck and University Medical Center Schleswig-Holstein, Lübeck, Germany.
Christian WiegDepartment of Neonatology, Hospital Aschaffenburg-Alzenau, Aschaffenburg, Germany.
Annika HartzDepartment of Pediatrics, University of Lübeck and University Medical Center Schleswig-Holstein, Lübeck, Germany.
Marc EhlersLaboratories of Immunology and Antibody Glycan Analysis, Institute for Nutrition Medicine, University of Lübeck and University Medical Center Schleswig-Holstein, Lübeck, Germany.
Christoph HärtelDepartment of Pediatrics, University of Lübeck and University Medical Center Schleswig-Holstein, Lübeck, Germany.
University of Lübeck · DEKlinikum Aschaffenburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preterm infants acquire reduced amounts of Immunoglobulin G (IgG) via trans-placental transfer as compared to term infants which might explain their high susceptibility for infections. The reduced amount of IgG antibodies also results in a lower amount of anti-inflammatory Fc N-galactosylated and -sialylated IgG antibodies. This reduction or, even more, a qualitative shift in the type of IgG Fc glycosylation might contribute to the increased risk for sustained inflammatory diseases in preterm infants. It was the aim of our explorative study to investigate the IgG Fc glycosylation patterns in preterm infants of different gestational ages compared to term infants and mothers of preterm infants. In plasma samples of preterm infants (

Indexed as

Gestational AgeBiomarkersChromatography, LiquidEnzyme-Linked Immunosorbent AssayFemaleGlycoproteinsHumansImmunoglobulin Fc FragmentsImmunoglobulin GInfant, NewbornInfant, PrematureMalePolysaccharidesPregnancyBiomarkersGlycoproteinsglycosylated IgGImmunoglobulin Fc FragmentsImmunoglobulin GPolysaccharidesgalactosylationIgG antibodiesIgG Fc glycosylationmothersnewbornpreterm infantssialylationtrans-placental transfer

Identifiers

PMID30713537
PMCPMC6346593
OpenAlexW2910151562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.