Evidence map›Paper›PMID 30713499›Full record

ArticleFrontiers in physiology2019

Autophagy Protects the Blood-Brain Barrier Through Regulating the Dynamic of Claudin-5 in Short-Term Starvation.

Zhenguo Yang, Chunnian Huang, Yongfu Wu, Bing Chen, Wenqing Zhang, Jingjing Zhang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 59 citations in OpenAlex.

  1. Review
  2. Review
  3. Impact of Tick-BorneInternational journal of molecular sciences · 2025
    Article
  4. Review
  5. Review
  6. Neurotrauma reports · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Macroautophagy in CNS health and disease.Nature reviews. Neuroscience · 2022
    Review
  18. Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion.Molecular therapy : the journal of the American Society of Gene Therapy · 2022
    Article
  19. Review
  20. Form and Function of the Vertebrate and Invertebrate Blood-Brain Barriers.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Zhenguo YangDepartment of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Chunnian HuangAffiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Yongfu WuAffiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Bing ChenAffiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Wenqing ZhangDepartment of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Jingjing ZhangAffiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Affiliated Hospital of Guangdong Medical College Hospital · CNGuangdong Medical College · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The blood-brain barrier (BBB) is essential for the exchange of nutrient and ions to maintain the homeostasis of central nervous system (CNS). BBB dysfunction is commonly associated with the disruption of endothelial tight junctions and excess permeability, which results in various CNS diseases. Therefore, maintaining the structural integrity and proper function of the BBB is essential for the homeostasis and physiological function of the CNS. Here, we showed that serum starvation disrupted the function of endothelial barrier as evidenced by decreased

Indexed as

autophagyblood-brain barrierclaudin-5permeabilitystarvation

Identifiers

PMID30713499
PMCPMC6345697
OpenAlexW2910494574

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.