Evidence map›Paper›PMID 30713316›Full record

ArticleInternal medicine (Tokyo, Japan)2019

Cardiotoxicity of Carfilzomib in Two Japanese Patients with Relapsed Multiple Myeloma.

Takenori Ikoma, Masao Saotome, Makoto Sano, Kenichiro Suwa, Yoshihisa Naruse, Hayato Ohtani, Tsuyoshi Urushida, Yasuyuki Nagata, Takaaki Ono, Yuichiro Maekawa

Abstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Takenori IkomaDepartment of Cardiology, Internal Medicine 3, Hamamatsu University School of Medicine, Japan.
Masao SaotomeDepartment of Cardiology, Internal Medicine 3, Hamamatsu University School of Medicine, Japan.
Makoto SanoDepartment of Cardiology, Internal Medicine 3, Hamamatsu University School of Medicine, Japan.
Kenichiro SuwaDepartment of Cardiology, Internal Medicine 3, Hamamatsu University School of Medicine, Japan.
Yoshihisa NaruseDepartment of Cardiology, Internal Medicine 3, Hamamatsu University School of Medicine, Japan.
Hayato OhtaniDepartment of Cardiology, Internal Medicine 3, Hamamatsu University School of Medicine, Japan.
Tsuyoshi UrushidaDepartment of Cardiology, Internal Medicine 3, Hamamatsu University School of Medicine, Japan.
Yasuyuki NagataDepartment of Hematology, Internal Medicine 3, Hamamatsu University School of Medicine, Japan.
Takaaki OnoDepartment of Hematology, Internal Medicine 3, Hamamatsu University School of Medicine, Japan.
Yuichiro MaekawaDepartment of Cardiology, Internal Medicine 3, Hamamatsu University School of Medicine, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although multiple myeloma (MM) had been an incurable hematological malignancy with a poor prognosis, recent advances in novel anti-neoplastic agents, including carfilzomib (a proteasome inhibitor), have improved the prognosis. We herein report two cases of congestive heart failure in patients treated with carfilzomib. Although there are some reports on the cardiotoxicity of carfilzomib, to our knowledge, this is the first report on the cardiac involvement of carfilzomib in Japanese MM patients. We review the critical points from our two cases, with the aim of avoiding carfilzomib-associated heart failure in MM patients.

Indexed as

Antineoplastic AgentsCardiotoxicityFemaleHeart FailureHumansMaleMiddle AgedMultiple MyelomaOligopeptidesPrognosisProteasome InhibitorsRecurrenceAntineoplastic AgentscarfilzomibOligopeptidesProteasome Inhibitorscardiotoxitycarfilzomibheart failuremultiple myeloma

Identifiers

PMID30713316
PMCPMC6599935

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.