Evidence map›Paper›PMID 30713042›Full record

ArticleStem cell reports2019

Sox10 Regulates Plasticity of Epithelial Progenitors toward Secretory Units of Exocrine Glands.

Harleen K Athwal, George Murphy, Ellis Tibbs, Ashley Cornett, Emily Hill, Kenji Yeoh, Elsa Berenstein, Matthew P Hoffman, Isabelle M A Lombaert

Open access · goldAbstract read
In one paragraph

Article in Stem cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
  2. Article
  3. Nutrients · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Salivary Gland Bioengineering.Bioengineering (Basel, Switzerland) · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Harleen K AthwalUniversity of Michigan, Biointerfaces Institute, 2800 Plymouth Road, Ann Arbor, MI, USA; University of Michigan, School of Dentistry, Department of Biologic and Materials Sciences, 2800 Plymouth Road, Ann Arbor, MI 48109, USA.
George MurphyUniversity of Michigan, Biointerfaces Institute, 2800 Plymouth Road, Ann Arbor, MI, USA; University of Michigan, School of Dentistry, Department of Biologic and Materials Sciences, 2800 Plymouth Road, Ann Arbor, MI 48109, USA.
Ellis TibbsNational Institutes of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA.
Ashley CornettUniversity of Michigan, Biointerfaces Institute, 2800 Plymouth Road, Ann Arbor, MI, USA; University of Michigan, School of Dentistry, Department of Biologic and Materials Sciences, 2800 Plymouth Road, Ann Arbor, MI 48109, USA.
Emily HillUniversity of Michigan, Biointerfaces Institute, 2800 Plymouth Road, Ann Arbor, MI, USA; University of Michigan, School of Dentistry, Department of Biologic and Materials Sciences, 2800 Plymouth Road, Ann Arbor, MI 48109, USA.
Kenji YeohUniversity of Michigan, Biointerfaces Institute, 2800 Plymouth Road, Ann Arbor, MI, USA; University of Michigan, School of Dentistry, Department of Biologic and Materials Sciences, 2800 Plymouth Road, Ann Arbor, MI 48109, USA.
Elsa BerensteinNational Institutes of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA.
Matthew P HoffmanNational Institutes of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA.
Isabelle M A LombaertUniversity of Michigan, Biointerfaces Institute, 2800 Plymouth Road, Ann Arbor, MI, USA; University of Michigan, School of Dentistry, Department of Biologic and Materials Sciences, 2800 Plymouth Road, Ann Arbor, MI 48109, USA; National Institutes of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA. Electronic address: lombaert@umich.edu.
University of Michigan–Ann Arbor · USBioSurfaces (United States) · USNational Institute of Dental and Craniofacial Research · USNational Institutes of Health · US

Funding

Growth Factor/Extracellular Matrix Interactions During Branching MorphogenesisZIADE000707 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI HOFFMAN, MATTHEW · 2009 to 2023
$14.0M
Manipulating Stem Cells to Provide Long Term Regeneration of Irradiated Salivary GlandsR01DE027034 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOMBAERT, ISABELLE M.A. · 2018 to 2022
$1.8M
Identifying stem cells for future salivary gland stem cell therapyR00DE022557 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOMBAERT, ISABELLE M.A. · 2015 to 2017
$741k
NIDCR NIH HHS R00 DE022557NIDCR NIH HHS R01 DE027034
6 · The paper itself

Abstract

Understanding how epithelial progenitors within exocrine glands establish specific cell lineages and form complex functional secretory units is vital for organ regeneration. Here we identify the transcription factor Sox10 as essential for both the maintenance and differentiation of epithelial KIT

Indexed as

AnimalsCell DifferentiationCell LineageCell PlasticityEpithelial CellsExocrine GlandsGene DeletionMaleMiceOrganogenesisReceptor, Fibroblast Growth Factor, Type 2Salivary GlandsSOXE Transcription FactorsReceptor, Fibroblast Growth Factor, Type 2Sox10 protein, mouseSOXE Transcription Factorscell fateexocrine glandsKITlacrimal glandmammary glandsalivary glandsecretory unitSOX10stem/progenitor cell

Identifiers

PMID30713042
PMCPMC6373627
OpenAlexW2911512449

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.