ArticleNeuron2019
Vasoactive Intestinal Polypeptide-Expressing Interneurons in the Hippocampus Support Goal-Oriented Spatial Learning.
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Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers.
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125citing papers in PubMed
11.8field-weighted citation impact, top 1% of its field
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Who cites it
125 citing papers in PubMed, 239 citations in OpenAlex.
- Vasoactive intestinal polypeptide plasma levels associated with affective symptoms and brain structure and function in healthy females.Scientific reports · 2021Trial
- Instructive signals drive learning through behavioral timescale synaptic plasticity in the hippocampus and beyond.Current research in neurobiology · 2026Article
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- Learning reorganizes dendritic and stabilizes axon initial segment inhibitory synapses in CA1 pyramidal neurons.Nature communications · 2026Article
- Sublayer- and pathway-specific control of CA1 input processing by VIP interneurons.The Journal of physiology · 2026Article
- Clustered inputs engage dendritic nonlinearities and calcium signaling to support efficient place-field formation in CA1 pyramidal neurons.Cell reports · 2026Article
- Inhibitory tone in the dentate gyrus dynamically prioritizes memory flexibility or stability by tuning a sensitivity-consistency continuum.PLoS biology · 2026Article
- Place and behavioral modulation of hippocampal neurons during immobility.Nature communications · 2026Article
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- A transcriptomic axis aligns with in vivo functional dynamics in hippocampal inhibitory circuits.bioRxiv : the preprint server for biology · 2026Article
- Behavioral timescale synaptic plasticity: properties, elements and functions.Nature neuroscience · 2026Review
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- Temporal Coding rather than Circuit Wiring allows Hippocampal CA3 Neurons to Dynamically Distinguish Different Cortical Inputs.bioRxiv : the preprint server for biology · 2026Article
- Learning-dependent feedback by OLM interneurons shapes CA1 representations.bioRxiv : the preprint server for biology · 2026Article
- Disorganized Inhibitory Dynamics in Hippocampal area CA1 of 22q11.2 Deletion Mutant Mice.bioRxiv : the preprint server for biology · 2026Article
- Unconstrained Plasticity Disrupts Memory Consolidation in a Mouse Model of Rett Syndrome.bioRxiv : the preprint server for biology · 2026Article
- The circuitry regulation of associative learning: dissociated and integrated function of the perirhinal cortex and hippocampus.Frontiers in neural circuits · 2026Review
- Dysfunctional neural dynamics associated with sensory phenotypes in Fragile X syndrome: insights from mouse models.Journal of neurodevelopmental disorders · 2025Review
- Medial entorhinal VIP-expressing interneurons receive input from the thalamic anterior dorsal nucleus and are critical for spatial memory.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Bimodal nonlinear dendrites in PV+ basket cells drive distinct memory-related oscillations.iScience · 2025Article
65 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 4 institutions in 2 countries.
Gergely Farkas TuriDepartment of Psychiatry, Columbia University, New York, NY 10032, USA.
Wen-Ke LiDepartment of Neuroscience, Columbia University, New York, NY 10027, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Spyridon ChavlisInstitute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology-Hellas (FORTH), Heraklion, Crete 700 13, Greece.
Ioanna PandiInstitute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology-Hellas (FORTH), Heraklion, Crete 700 13, Greece; School of Medicine, University of Crete, Heraklion, Crete 741 00, Greece.
Justin O'HareDepartment of Neuroscience, Columbia University, New York, NY 10027, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
James Benjamin PriestleyDepartment of Neuroscience, Columbia University, New York, NY 10027, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Andres Daniel GrosmarkDepartment of Neuroscience, Columbia University, New York, NY 10027, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Zhenrui LiaoDepartment of Neuroscience, Columbia University, New York, NY 10027, USA.
Max LadowDepartment of Neuroscience, Columbia University, New York, NY 10027, USA.
Jeff Fang ZhangDepartment of Neuroscience, Columbia University, New York, NY 10027, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
Boris Valery ZemelmanCenter for Learning and Memory, University of Texas, Austin, TX 78712, USA; Department of Neuroscience, University of Texas, Austin, TX 78712, USA.
Panayiota PoiraziInstitute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology-Hellas (FORTH), Heraklion, Crete 700 13, Greece. Electronic address: poirazi@imbb.forth.gr.
Attila LosonczyDepartment of Neuroscience, Columbia University, New York, NY 10027, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Kavli Institute for Brain Science, Columbia University, New York, NY, USA. Electronic address: al2856@columbia.edu.
Columbia University · USFoundation for Research and Technology Hellas · GRThe University of Texas at Austin · USUniversity of Crete · GR
Funding
Towards a Complete Description of the Circuitry Underlying Sharp Wave-Mediated Memory ReplayU19NS104590 · NINDS · STANFORD UNIVERSITY · PI LOSONCZY, ATTILA · 2017 to 2021
$13.2MNeural ensembles underlying natural tracking behaviorU01NS094330 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI FIETE, ILA R., HUK, ALEXANDER C · 2015 to 2018
$3.2MClosed-loop intervention in epilepsy.R01NS094668 · NINDS · STANFORD UNIVERSITY · PI LOSONCZY, ATTILA, SOLTESZ, IVAN · 2015 to 2019
$2.3MHippocampal inhibitory control of contextual fear learningR01MH100631 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LOSONCZY, ATTILA · 2014 to 2018
$2.0MAn optical-genetic toolbox for reading and writing neural population codes in functional mapsU01NS099720 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI GEISLER, WILSON S, SEIDEMANN, EYAL J · 2016 to 2018
$1.8M2-photon microscope for in vivo functional imaging of neuronal circuitsS10OD018464 · OD · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MOORE, HOLLY MARIE · 2015 to 2015
$847kCausally linking dendritic Ca2+ dynamics to CA1 circuit function and spatial learning using novel tools to precisely manipulate an endogenous Ca2+ buffering processF32MH118716 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI O'HARE, JUSTIN · 2018 to 2020
$206kNIH HHS S10 OD018464NIMH NIH HHS F32 MH118716NIMH NIH HHS R01 MH100631NINDS NIH HHS R01 NS094668NINDS NIH HHS U01 NS094330NINDS NIH HHS U01 NS099720NINDS NIH HHS U19 NS104590
Abstract
Diverse computations in the neocortex are aided by specialized GABAergic interneurons (INs), which selectively target other INs. However, much less is known about how these canonical disinhibitory circuit motifs contribute to network operations supporting spatial navigation and learning in the hippocampus. Using chronic two-photon calcium imaging in mice performing random foraging or goal-oriented learning tasks, we found that vasoactive intestinal polypeptide-expressing (VIP
Indexed as
AnimalsAppetitive BehaviorCA1 Region, HippocampalGoalsHippocampusInterneuronsMiceNeocortexNeural InhibitionOptogeneticsPyramidal CellsSpatial LearningVasoactive Intestinal PeptideVasoactive Intestinal Peptidedisinhibitionhippocampusinhibitionplace cellrewardspatial learningtwo-photonVIP
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.