Trial reportLancet (London, England)2019
Physiological, hyaluronan-selected intracytoplasmic sperm injection for infertility treatment (HABSelect): a parallel, two-group, randomised trial.
Trial report in Lancet (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Advanced Sperm Selection Strategies as a Treatment for Infertile Couples: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Endometrial scratch to increase live birth rates in women undergoing first-time in vitro fertilisation: RCT and systematic review.Health technology assessment (Winchester, England) · 2022Pooled it
- Microfluidic Intracytoplasmic Sperm Injection (MICSI): A Novel Platform for Sperm Isolation, Selection, and Injection Into Oocytes.Andrology · 2026Article
- The role of sperm DNA fragmentation testing in predicting IVF and PGT-A outcomes.Scientific reports · 2026Article
- Genetic nexus of assisted reproduction technique efficacy in infertile women: insights from a comprehensive retrospective study.Journal of applied genetics · 2026Article
- Clinical Outcomes of ICSI Using Advanced Quantitative Phase Microscopy.Bioengineering (Basel, Switzerland) · 2026Article
- Sperm Selection Procedures in Cases of High Sperm DNA Fragmentation Index.Advances in experimental medicine and biology · 2026Review
- Sperm DNA Fragmentation: The Concept and Its Use in Assisted Reproduction.Advances in experimental medicine and biology · 2026Review
- A Bayesian reevaluation of randomized controlled trials in assisted reproductive technology: quantifying evidence strength for null and alternative hypotheses.Frontiers in endocrinology · 2026Article
- Evaluating Sperm DNA Damage: When and Why It Adds to the Management of the Infertile Man.Advances in experimental medicine and biology · 2026Review
- Sperm selection for assisted reproductive technology: do we have a winner?Journal of assisted reproduction and genetics · 2025Review
- A Comprehensive Comparison of PICSI and ICSI Techniques Through a Triple-Blinded Trial: Effects on Embryo Quality, Cumulative Pregnancy Rate, and Live Birth Rate.Biomedicines · 2025Article
- Sperm Separation and Selection Techniques to Mitigate Sperm DNA Damage.Life (Basel, Switzerland) · 2025Review
- Review
- A narrative review of sperm selection technology for assisted reproduction techniques.Translational andrology and urology · 2024Review
- Sperm Migration and Hyaluronic Acid Binding: Implications for Male Fertility Evaluation.International journal of molecular sciences · 2024Article
- Emerging trends in sperm selection: enhancing success rates in assisted reproduction.Reproductive biology and endocrinology : RB&E · 2024Review
- Article
- Applying a simplified economic evaluation approach to evaluate infertility treatments in clinical practice.Human reproduction (Oxford, England) · 2024Article
- Article
Corrections and comments
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Authors and funding
16 authors at 12 institutions in 1 country.
Funding
Abstract
backgroundSperm selection strategies aimed at improving success rates of intracytoplasmic sperm injection (ICSI) include binding to hyaluronic acid (herein termed hyaluronan). Hyaluronan-selected sperm have reduced levels of DNA damage and aneuploidy. Use of hyaluronan-based sperm selection for ICSI (so-called physiological ICSI [PICSI]) is reported to reduce the proportion of pregnancies that end in miscarriage. However, the effect of PICSI on livebirth rates is uncertain. We aimed to investigate the efficacy of PICSI versus standard ICSI for improving livebirth rates among couples undergoing fertility treatment.
methodsThis parallel, two-group, randomised trial included couples undergoing an ICSI procedure with fresh embryo transfer at 16 assisted conception units in the UK. Eligible women (aged 18-43 years) had a body-mass index of 19-35 kg/m
findingsBetween Feb 1, 2014, and Aug 31, 2016, 2772 couples were randomly assigned to receive PICSI (n=1387) or ICSI (n=1385), of whom 2752 (1381 in the PICSI group and 1371 in the ICSI group) were included in the primary analysis. The term livebirth rate did not differ significantly between PICSI (27·4% [379/1381]) and ICSI (25·2% [346/1371]) groups (odds ratio 1·12, 95% CI 0·95-1·34; p=0·18). There were 56 serious adverse events in total, including 31 in the PICSI group and 25 in the ICSI group; most were congenital abnormalities and none were attributed to treatment.
interpretationCompared with ICSI, PICSI does not significantly improve term livebirth rates. The wider use of PICSI, therefore, is not recommended at present.
fundingNational Institute for Health Research Efficacy and Mechanism Evaluation Programme.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.