ArticleEnvironment international2019
Early-life triclosan exposure and parent-reported behavior problems in 8-year-old children.
Article in Environment international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Gestational triclosan exposure and infant birth weight: A systematic review and meta-analysis.Environment international · 2021Pooled it
- Associations of Urinary Triclosan Concentrations Across Gestation and Childhood with the Adolescent Gut Microbiome.Environmental health perspectives · 2026Article
- Metabolome informs about the chemical exposome and links to brain health.Environment international · 2025Review
- Examining the association between gestational phenol exposure and infant non-nutritive suck in two Environmental influences on Child Health Outcomes cohorts.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Prenatal and Childhood Phthalate Mixtures and Adolescent Sleep Health in the HOME Study.Environmental health perspectives · 2025Article
- Time-varying associations of gestational and childhood triclosan with pubertal and adrenarchal outcomes in early adolescence.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Conceptualizing the Role of the Microbiome as a Mediator and Modifier in Environmental Health Studies: A Scoping Review of Studies of Triclosan and the Microbiome.Current environmental health reports · 2024Article
- Evaluating Mixtures of Urinary Phthalate Metabolites and Serum Per-/Polyfluoroalkyl Substances in Relation to Adolescent Hair Cortisol: The HOME Study.American journal of epidemiology · 2024Article
- Early-Life Exposure to a Mixture of Phenols and Phthalates in Relation to Child Social Behavior: Applying an Evidence-Based Prioritization to a Cohort with Improved Exposure Assessment.Environmental health perspectives · 2023Review
- Triclosan: A Small Molecule with Controversial Roles.Antibiotics (Basel, Switzerland) · 2022Review
- Does early life phthalate exposure mediate racial disparities in children's cognitive abilities?Environmental epidemiology (Philadelphia, Pa.) · 2022Article
- Article
- REPRODUCTIVE TOXICOLOGY: Pregnancy exposure to endocrine disrupting chemicals: implications for women's health.Reproduction (Cambridge, England) · 2021Review
- Racial/Ethnic Disparities in Pregnancy and Prenatal Exposure to Endocrine-Disrupting Chemicals Commonly Used in Personal Care Products.Current environmental health reports · 2021Review
- Environmental Distribution of Personal Care Products and Their Effects on Human Health.Iranian journal of pharmaceutical research : IJPR · 2021Review
- Triclosan disrupts immune cell function by depressing CaToxicology and applied pharmacology · 2020Article
- Gestational and childhood urinary triclosan concentrations and academic achievement among 8-year-old children.Neurotoxicology · 2020Article
- Characterization of binding interaction of triclosan and trypsin.Environmental science and pollution research international · 2020Article
- Statistical analysis of childhood and early adolescent externalizing behaviors in a middle low income country.Heliyon · 2020Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundTriclosan exposure may decrease circulating thyroxine levels or cause neuron apoptosis, which in turn may adversely affect neurodevelopment. However, few studies have examined the association of early life triclosan exposure with child behavior.
objectiveTo quantify the association between early-life triclosan exposure and child behavior at age 8-years in 202 mother-child pairs from the HOME study (Cincinnati, OH; enrolled: 2003-2006).
methodsWe quantified urinary triclosan concentrations up to 3 times in mothers (16-weeks, 26-weeks, and delivery) and up to 6 times in children (1, 2, 3, 4, 5, and 8 years). Parents rated children's problem behaviors at age 8-years using the Behavioral Assessment System for Children-2 (BASC-2). Adjusting for covariates and accounting for exposure measurement error, we estimated changes in behavior problem scores per 10-fold increase in mean gestational and childhood triclosan concentrations. In addition, we estimated sex-specific associations.
resultsChild sex modified the association of gestational and childhood triclosan with several BASC-2 scales (sex × triclosan p-values < 0.2). In boys, increasing gestational triclosan was associated with higher behavioral symptom index (β: 4.5; 95% CI: 1.0, 8.1), externalizing problems (β: 5.0; 95% CI: 1.2, 9.0), attention problem (β: 6.6; 95% CI: 2.4, 11), hyperactivity (β: 6.4; 95% CI: 2.1, 11), and somatization (β: 3.8; 95% CI: 0.3, 7.3) scores. In contrast, triclosan-BASC-2 associations in girls were generally null and not statistically significant. We observed similar patterns of associations between childhood triclosan and these same behavioral scores; however, their magnitude decreased substantially after adjusting for gestational triclosan and associations were not statistically significant.
conclusionIn this cohort, increasing gestational and childhood urinary triclosan concentrations were associated with higher behavior problem scores in 8-year old boys, but not girls.
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