Evidence map›Paper›PMID 30712873›Full record

ArticleCell2019

Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium.

Tetsuro Kobayashi, Benjamin Voisin, Do Young Kim, Elizabeth A Kennedy, Jay-Hyun Jo, Han-Yu Shih, Amanda Truong, Thomas Doebel, Keiko Sakamoto, Chang-Yi Cui and 8 more

Open access · bronzeAbstract read
In one paragraph

Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

139 citing papers in PubMed, 232 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Shared Pathways between Psoriasis and Atopic Dermatitis.Dermatology practical & conceptual · 2026
    Review
  5. Review
  6. Article
  7. Hidden immune memory niches in inflammatory skin diseases.bioRxiv : the preprint server for biology · 2026
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Topographical variations in the skin barrier and their role in disease pathogenesis.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025
    Review
  16. Review
  17. Article
  18. Hidradenitis Suppurativa Tunnels: Unveiling a Unique Disease Entity.JID innovations : skin science from molecules to population health · 2025
    Review
  19. Article
  20. Review

79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 3 countries.

Tetsuro KobayashiCutaneous Leukocyte Biology Section, Dermatology Branch, NIAMS, NIH, Bethesda, MD 20892, USA.
Benjamin VoisinCutaneous Leukocyte Biology Section, Dermatology Branch, NIAMS, NIH, Bethesda, MD 20892, USA.
Do Young KimCutaneous Leukocyte Biology Section, Dermatology Branch, NIAMS, NIH, Bethesda, MD 20892, USA; Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Elizabeth A KennedyCutaneous Microbiome and Inflammation Section, Dermatology Branch, NIAMS, NIH, Bethesda, MD 20892, USA.
Jay-Hyun JoCutaneous Microbiome and Inflammation Section, Dermatology Branch, NIAMS, NIH, Bethesda, MD 20892, USA.
Han-Yu ShihLaboratory of Immunology, Molecular Immunology and Inflammation Branch, NIAMS, NIH, Bethesda, MD 20892, USA.
Amanda TruongCutaneous Leukocyte Biology Section, Dermatology Branch, NIAMS, NIH, Bethesda, MD 20892, USA.
Thomas DoebelCutaneous Leukocyte Biology Section, Dermatology Branch, NIAMS, NIH, Bethesda, MD 20892, USA.
Keiko SakamotoCutaneous Leukocyte Biology Section, Dermatology Branch, NIAMS, NIH, Bethesda, MD 20892, USA.
Chang-Yi CuiHuman Genetics Section, Laboratory of Genetics and Genomics, NIA, NIH, Baltimore, MD 21224, USA.
David SchlessingerHuman Genetics Section, Laboratory of Genetics and Genomics, NIA, NIH, Baltimore, MD 21224, USA.
Kazuyo MoroLaboratory for Innate Immune Systems, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Susumu NakaeLaboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, 113-8654, Japan.
Keisuke HoriuchiDepartment of Orthopedic Surgery, National Defense Medical College, Tokorozawa, 359-8513, Japan.
Jinfang ZhuMolecular and Cellular Immunoregulation Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD 20892, USA.
Warren J LeonardLaboratory of Molecular Immunology and Immunology Center, NHLBI, NIH, Bethesda, MD 20892, USA.
Heidi H KongCutaneous Microbiome and Inflammation Section, Dermatology Branch, NIAMS, NIH, Bethesda, MD 20892, USA.
Keisuke NagaoCutaneous Leukocyte Biology Section, Dermatology Branch, NIAMS, NIH, Bethesda, MD 20892, USA. Electronic address: keisuke.nagao@nih.gov.
National Institute of Arthritis and Musculoskeletal and Skin Diseases · USNational Human Genome Research Institute · USNational Institutes of Health · USNational Center for Biotechnology Information · USNational Defense Medical College · JPNational Institute of Allergy and Infectious Diseases · USRIKEN Center for Integrative Medical Sciences · JPSystems Biology Institute · JPYonsei University · KR

Funding

Transcriptional Regulation of Immune Cell Development, Activation and FunctionsZIAAI001169 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ZHU, JINFANG · 2012 to 2025
$21.8M
Exploring mechanisms that govern immune homeostasis in skinZIABC011561 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NAGAO, KEISUKE · 2014 to 2021
$10.1M
IL-2 Family Cytokines and their Receptors--Biology of the IL-7/TSLP SystemsZIAHL005409 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEONARD, WARREN J · 2009 to 2025
$10.0M
Studies of Skin Microflora in Healthy Individuals and Atopic Dermatitis PatientsZIABC010938 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KONG, HEIDI · 2009 to 2021
$5.4M
Intramural NIH HHS Z99 AG999999
6 · The paper itself

Abstract

Immune cells and epithelium form sophisticated barrier systems in symbiotic relationships with microbiota. Evidence suggests that immune cells can sense microbes through intact barriers, but regulation of microbial commensalism remain largely unexplored. Here, we uncovered spatial compartmentalization of skin-resident innate lymphoid cells (ILCs) and modulation of sebaceous glands by a subset of RORγt

Indexed as

AnimalsBacteriaCytokinesEpitheliumHair FollicleImmunity, InnateInterleukin-7LymphocytesMaleMiceMice, Inbred C57BLMice, KnockoutMicrobiotaReceptors, CCR6Receptors, NotchReceptors, Tumor Necrosis FactorCCR6 protein, mouseCytokinesInterleukin-7Receptors, CCR6Receptors, NotchReceptors, Tumor Necrosis FactorThymic Stromal Lymphopoietin

Identifiers

PMID30712873
PMCPMC6532063
OpenAlexW2914479886

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.