Evidence map›Paper›PMID 30712758›Full record

ReviewInfectious disease clinics of North America2019

Strongyloidiasis: A Neglected Tropical Disease.

Alejandro Krolewiecki, Thomas B Nutman

Abstract readReview
In one paragraph

Review in Infectious disease clinics of North America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 3 pooled it
19.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 3 syntheses or guidelines pooled it, 192 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Strongyloides stercoralis infection alters liver enzyme levels in alcoholic patientsBiomedica : revista del Instituto Nacional de Salud · 2026
    Article
  8. Article
  9. Article
  10. Tropical medicine and infectious disease · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Clinical Insights intoInfection and drug resistance · 2026
    Article
  16. Article
  17. Article
  18. Evidence of Autochthonous Human Strongyloides stercoralis in South Carolina.The American journal of tropical medicine and hygiene · 2025
    Article
  19. Article
  20. Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Alejandro KrolewieckiInstitute for Tropical Diseases Research, Universidad Nacional de Salta/CONICET, Alvarado 751, Oran 4530, Salta, Argentina.
Thomas B NutmanLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4 - Room B1-03, 4 Center Drive, Bethesda, MD 20892-0425, USA. Electronic address: tnutman@niaid.nih.gov.
Consejo Nacional de Investigaciones Científicas y Técnicas · ARNational Institutes of Health · US

Funding

Clinical And Therapeutic Studies Of Human Filariasis and Related DiseasesZIAAI000439 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NUTMAN, THOMAS · 2009 to 2025
$14.8M
Clinical/Therapeutic Studies Of Filariasis &Related DisZ01AI000439 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI NUTMAN, THOMAS B · 1985 to 2008
$800k
Intramural NIH HHS Z01 AI000439
6 · The paper itself

Abstract

Most of the 30 to 100 million people infected with Strongyloides stercoralis have subclinical (or asymptomatic) infections. These infections are commonly chronic and longstanding. A change in immune status can increase parasite numbers, leading to hyperinfection syndrome, dissemination, and death if unrecognized. The use of corticosteroids and HTLV-1 infection are most commonly associated with the hyperinfection syndrome. Strongyloides adult parasites reside in the small intestine and induce immune responses that are like other nematodes. Definitive diagnosis of S stercoralis infection is based on stool examinations for larvae. S stercoralis remains largely neglected.

Indexed as

AnimalsAntiparasitic AgentsAsymptomatic InfectionsClinical Trials as TopicDisease ManagementHumansImmunoassayIvermectinMolecular Diagnostic TechniquesNeglected DiseasesSoilStrongyloidiasisAntiparasitic AgentsIvermectinSoilAnthelmintic therapyAutoinfectionCorticosteroidsHyperinfectionStrongyloidesStrongyloidiasis

Identifiers

PMID30712758
PMCPMC6367705
OpenAlexW2911289486

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.