Evidence map›Paper›PMID 30712506›Full record

ReviewTissue engineering. Part B, Reviews2019

Platelet-Rich Plasma for the Treatment of Tissue Infection: Preparation and Clinical Evaluation.

Wenhai Zhang, Yue Guo, Mitchell Kuss, Wen Shi, Amy L Aldrich, Jason Untrauer, Tammy Kielian, Bin Duan

Abstract readReview
In one paragraph

Review in Tissue engineering. Part B, Reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Efficacy of Platelet-Rich Plasma and Polyvinyl Alcohol Wound Dressing in Open Wound Healing: First Results from an Experimental Rat Model.European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes · 2026
    Article
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  19. Therapeutic potential of platelet rich plasma against experimentalJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenhai Zhang1 Department of Orthopedics, Tianjin Hospital, Tianjin, People's Republic of China.
Yue Guo3 Tissue Engineering Labs of Orthopedics Institute, Tianjin Hospital, Tianjin, People's Republic of China.
Mitchell Kuss2 Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska.
Wen Shi2 Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska.
Amy L Aldrich5 Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska.
Jason Untrauer6 Division of Oral and Maxillofacial Surgery, Department of Surgery, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska.
Tammy Kielian5 Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska.
Bin Duan2 Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska.

Funding

Immune mechanisms that promote S. aureus persistence during craniotomy-associated biofilm infectionR01NS107369 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KIELIAN, TAMMY L · 2018 to 2022
$2.1M
3D Bioprinting of Biomimetic Constructs for Rotator Cuff AugmentationR01AR073225 · NIAMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DUAN, BIN, STREUBEL, PHILIPP N · 2018 to 2022
$1.6M
NIAMS NIH HHS R01 AR073225NINDS NIH HHS R01 NS107369
6 · The paper itself

Abstract

impact statementThe clinical application of platelet-rich plasma (PRP) has been widely studied for its effects on trauma or injury repair/regeneration, however the antibacterial property of PRP has been overlooked. Increasing evidence suggests PRP as a good antibacterial agent and that it could help prevent/treat tissue infection. This review emphasizes the importance of PRP's antibacterial property and summarizes the preclinical and clinical findings regarding the application of PRP in the prevention and treatment of wound and bone infection. The use of biocompatible PRP may be advantageous for tissue infection treatment due to its inherent antibacterial and healing promoting properties.

Indexed as

Platelet-Rich PlasmaWound HealingAnimalsBacterial InfectionsHumansantibacterialbone infectionosteomyelitisPRPwound infection

Identifiers

PMID30712506
PMCPMC6589492

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.