Evidence map›Paper›PMID 30712397›Full record

ArticleDrug development and industrial pharmacy2019

Nicotine-like discriminative stimulus effects of acetylcholinesterase inhibitors and a muscarinic receptor agonist in Rhesus monkeys.

Megan J Moerke, Lance R McMahon

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug development and industrial pharmacy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Megan J Moerkea Department of Pharmacodynamics , College of Pharmacy, University of Florida , Gainesville , FL , USA.
Lance R McMahona Department of Pharmacodynamics , College of Pharmacy, University of Florida , Gainesville , FL , USA.ORCID http://orcid.org/0000-0003-0360-6318
University of Florida · US

Funding

Opioid use disorders: UF Pharmacy medications discovery and developmentUH3DA048353 · NIDA · UNIVERSITY OF FLORIDA · PI MCCURDY, CHRISTOPHER R, MCMAHON, LANCE R. · 2021 to 2023
$4.5M
Opioid use disorders: UF Pharmacy medications discovery and developmentUG3DA048353 · NIDA · UNIVERSITY OF FLORIDA · PI MCCURDY, CHRISTOPHER R, MCMAHON, LANCE R. · 2019 to 2020
$3.6M
Kratom alkaloids: in vitro and in vivo pharmacological mechanismsR01DA047855 · NIDA · UNIVERSITY OF FLORIDA · PI MCCURDY, CHRISTOPHER R, MCMAHON, LANCE R. · 2019 to 2023
$3.6M
Nicotine dependence: neuropharmacology in monkeysR01DA025267 · NIDA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MCMAHON, LANCE R. · 2009 to 2018
$3.4M
NIDA NIH HHS R01 DA025267NIDA NIH HHS R01 DA047855NIDA NIH HHS UG3 DA048353NIDA NIH HHS UH3 DA048353
6 · The paper itself

Abstract

Acetylcholinesterase (AChE) inhibitors and positive allosteric nicotinic acetylcholine receptor (nAChR) modulators are potential pharmacotherapies for nicotine dependence. Because some smoking cessation aids (e.g. varenicline) appear to work by mimicking the effects of nicotine, we used drug discrimination to examine whether AChE inhibitors and nAChR allosteric modulators mimic the effects of nicotine. Rhesus monkeys discriminated 1.78 mg/kg of nicotine s.c. under an FR5 schedule of stimulus-shock termination. Nicotine and the AChE inhibitors donepezil and galantamine dose-dependently increased responding on the nicotine-appropriate lever with ED

Indexed as

Allosteric RegulationAnimalsCholinesterase InhibitorsDose-Response Relationship, DrugFemaleInjections, SubcutaneousMacaca mulattaMaleModels, AnimalMuscarinic AgonistsMuscarinic AntagonistsNicotineNicotinic AgonistsReceptors, MuscarinicReceptors, NicotinicSmoking CessationCholinesterase InhibitorsMuscarinic AgonistsMuscarinic AntagonistsNicotineNicotinic AgonistsReceptors, MuscarinicReceptors, NicotinicSmoking Cessation Agentsdonepezildrug developmentgalantamineNicotinesmoking cessation

Identifiers

PMID30712397
PMCPMC7135966
OpenAlexW2913830942

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.