ArticleAging cell2019
Epigenetic age is a cell-intrinsic property in transplanted human hematopoietic cells.
Article in Aging cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Haematopoietic ageing in health and lifespan.Nature cell biology · 2025Review
- DNA methylation drives hematopoietic stem cell aging phenotypes after proliferative stress.GeroScience · 2025Article
- Epigenetic age acceleration in hematopoietic stem cell transplantation.Haematologica · 2025Article
- Determining the relationship of p16Journal of cancer survivorship : research and practice · 2024Article
- Article
- Tissue mosaicism following stem cell aging: blood as an exemplar.Nature aging · 2024Review
- SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation.Cell stem cell · 2023Article
- Review
- Childhood sleep health and epigenetic age acceleration in late adolescence: Cross-sectional and longitudinal analyses.Acta paediatrica (Oslo, Norway : 1992) · 2023Article
- DNA Methylation Changes in Autologous Hematopoietic Stem Cell Transplant Patients.Biological research for nursing · 2023Article
- Donor cord blood aging accelerates in recipients after transplantation.Scientific reports · 2023Article
- The impact of epigenetic modifications on allogeneic hematopoietic stem cell transplantation.Frontiers in immunology · 2023Review
- Epigenetic age provides insight into tissue origin in endometriosis.Scientific reports · 2022Article
- The landscape of aging.Science China. Life sciences · 2022Review
- Aging and cancer epigenetics: Where do the paths fork?Aging cell · 2022Review
- Clonal hematopoiesis: Mutation-specific adaptation to environmental change.Cell stem cell · 2022Review
- Impact of Large Granular Lymphocyte Leukemia on Blood DNA Methylation and Epigenetic Clock Modeling in Fischer 344 Rats.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Review
- Origins of human disease: the chrono-epigenetic perspective.Nature reviews. Genetics · 2021Review
- Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study.GeroScience · 2021Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
The age of tissues and cells can be accurately estimated by DNA methylation analysis. The multitissue DNA methylation (DNAm) age predictor combines the DNAm levels of 353 CpG dinucleotides to arrive at an age estimate referred to as DNAm age. Recent studies based on short-term observations showed that the DNAm age of reconstituted blood following allogeneic hematopoietic stem cell transplantation (HSCT) reflects the age of the donor. However, it is not known whether the DNAm age of donor blood remains independent of the recipient's age over the long term. Importantly, long-term studies including child recipients have the potential to clearly reveal whether DNAm age is cell-intrinsic or whether it is modulated by extracellular cues in vivo. Here, we address this question by analyzing blood methylation data from HSCT donor and recipient pairs who greatly differed in chronological age (age differences between 1 and 49 years). We found that the DNAm age of the reconstituted blood was not influenced by the recipient's age, even 17 years after HSCT, in individuals without relapse of their hematologic disorder. However, the DNAm age of recipients with relapse of leukemia was unstable. These data are consistent with our previous findings concerning the abnormal DNAm age of cancer cells, and it can potentially be exploited to monitor the health of HSCT recipients. Our data demonstrate that transplanted human hematopoietic stem cells have an intrinsic DNAm age that is unaffected by the environment in a recipient of a different age.
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