Evidence map›Paper›PMID 30712316›Full record

ArticlePigment cell & melanoma research2019

Melanoma central nervous system metastases: An update to approaches, challenges, and opportunities.

Zeynep Eroglu, Sheri L Holmen, Qing Chen, Nikhil I Khushalani, Ravi Amaravadi, Reena Thomas, Kamran A Ahmed, Hussein Tawbi, Sunandana Chandra, Joseph Markowitz and 17 more

Abstract read
In one paragraph

Article in Pigment cell & melanoma research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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  17. Functionalization of Nanomaterials for Skin Cancer Theranostics.Frontiers in bioengineering and biotechnology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Zeynep ErogluMoffitt Cancer Center, Tampa, Florida.
Sheri L HolmenUniversity of Utah Health Sciences Center, Salt Lake City, Utah.
Qing ChenThe Wistar Institute, Philadelphia, Pennsylvania.
Nikhil I KhushalaniMoffitt Cancer Center, Tampa, Florida.
Ravi AmaravadiThe University of Pennsylvania, Philadelphia, Pennsylvania.
Reena ThomasStanford University, Palo Alto, California.
Kamran A AhmedMoffitt Cancer Center, Tampa, Florida.
Hussein TawbiMD Anderson Cancer Center, Houston, Texas.
Sunandana ChandraNorthwestern University, Chicago, Illinois.
Joseph MarkowitzMoffitt Cancer Center, Tampa, Florida.
Inna SmalleyMoffitt Cancer Center, Tampa, Florida.
James K C LiuMoffitt Cancer Center, Tampa, Florida.
Yian Ann ChenMoffitt Cancer Center, Tampa, Florida.
Yana G NajjarUniversity of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Florian A KarrethMoffitt Cancer Center, Tampa, Florida.
Daniel Abate-DagaMoffitt Cancer Center, Tampa, Florida.
Isabella C GlitzaMD Anderson Cancer Center, Houston, Texas.
Jeffrey A SosmanNorthwestern University, Chicago, Illinois.
Vernon K SondakMoffitt Cancer Center, Tampa, Florida.
Marcus BosenbergYale University, New Haven, Connecticut.
Meenhard HerlynThe Wistar Institute, Philadelphia, Pennsylvania.
Michael B AtkinsGeorgetown University Cancer Center, Washington, District of Columbia.
Harriet KlugerYale University, New Haven, Connecticut.
Kim MargolinCity of Hope, Duarte, California.
Peter A ForsythMoffitt Cancer Center, Tampa, Florida.
Michael A DaviesMD Anderson Cancer Center, Houston, Texas.
Keiran S M SmalleyMoffitt Cancer Center, Tampa, Florida.

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9M
Investigating Microenvironmental Interactions in Leptomeningeal MetastasisR01CA245499 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI BOIRE, ADRIENNE A. · 2020 to 2024
$2.0M
Melanoma Research FoundationNCI NIH HHS P30 CA010815NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA245499
6 · The paper itself

Abstract

In February 2018, the Melanoma Research Foundation and the Moffitt Cancer Center hosted the Second Summit on Melanoma Central Nervous System (CNS) Metastases in Tampa, Florida. In this white paper, we outline the current status of basic science, translational, and clinical research into melanoma brain metastasis development and therapeutic management. We further outline the important challenges that remain for the field and the critical barriers that need to be overcome for continued progress to be made in this clinically difficult area.

Indexed as

Central Nervous System NeoplasmsDisease ManagementHumansImmunotherapyMelanomaMolecular Targeted Therapybrain metastasesimmunotherapymelanomametastasistargeted therapy

Identifiers

PMID30712316
PMCPMC7771318

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.