Evidence map›Paper›PMID 30712273›Full record

ArticleJournal of viral hepatitis2019

High prevalence and poor linkage to care of transfusion-transmitted infections among blood donors in Dar-es-Salaam, Tanzania.

Zameer Mohamed, Jin U Kim, Alex Magesa, Mabula Kasubi, Sarah F Feldman, Stephane Chevaliez, Promise Mwakale, Simon D Taylor-Robinson, Mark R Thursz, Yusuke Shimakawa and 2 more

Abstract read
In one paragraph

Article in Journal of viral hepatitis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zameer MohamedDepartment of Hepatology, Imperial College London, St Mary's Hospital, London, UK.ORCID 0000-0002-3713-0277
Jin U KimDepartment of Hepatology, Imperial College London, St Mary's Hospital, London, UK.
Alex MagesaDepartment of Biochemistry and Haematology, Muhimbili National Hospital, Dar es Salaam, Tanzania.
Mabula KasubiDepartment of Biochemistry and Haematology, Muhimbili National Hospital, Dar es Salaam, Tanzania.
Sarah F FeldmanUnité d'Épidémiologie des Maladies Émergentes, Institut Pasteur, Paris, France.
Stephane ChevaliezFrench National Reference Center for Viral Hepatitis B, C and delta, Department of Virology, Hopital Henri Mondor, Université Paris-Est, Créteil, France.
Promise MwakaleDepartment of Bioethics, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Simon D Taylor-RobinsonDepartment of Hepatology, Imperial College London, St Mary's Hospital, London, UK.
Mark R ThurszDepartment of Hepatology, Imperial College London, St Mary's Hospital, London, UK.
Yusuke ShimakawaUnité d'Épidémiologie des Maladies Émergentes, Institut Pasteur, Paris, France.ORCID 0000-0002-4198-4785
John RwegashaDepartment of Gastroenterology, Muhimbili National Hospital, Dar es Salaam, Tanzania.
Maud LemoineDepartment of Hepatology, Imperial College London, St Mary's Hospital, London, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Blood transfusion is one of the most commonly relied upon therapies in sub-Saharan Africa. Existing safeguards recommended include systematic screening for transfusion-transmitted infections and restricted voluntary nonremunerated blood donor selection. We report the transfusion-transmitted infection screening and notification practice at a large urban blood transfusion centre in Dar-es-Salaam, Tanzania. Between October 2016 and March 2017 anonymized records of all donors registered at the blood transfusion unit were accessed to retrospectively note demographic information, donor status, first-time status, transfusion-transmitted infection result and notification. 6402 consecutive donors were screened for transfusion-transmitted infections; the majority were family/replacement blood donors (88.0%) and male (83.8%). Overall transfusion-transmitted infections prevalence was 8.4% (95% CI 7.8-9.1), with hepatitis B being the most prevalent infection (4.1% (95% CI 3.6-4.6)). Transfusion-transmitted infections were more common in family/replacement blood donors (9.0% (95% CI 8.3-9.8)) as compared to voluntary nonremunerated blood donor (4.1% (95% CI 2.8-5.7)). A minority of infected-donors were notified of a positive result (8.5% (95% CI 6.3-11.2)). Although transfusion-transmitted infections are more prevalent among family/replacement blood donors, overall risk of transfusion-transmitted infections across all groups is considerable. In addition, existing efforts to notify donors of a positive transfusion-transmitted infection are poor. Future policies must focus on improving linkage to care for newly diagnosed patients with transfusion-transmitted infections.

Indexed as

Blood DonorsAdolescentAdultBlood TransfusionDisease NotificationFamilyFemaleHepatitis BHepatitis CHIV InfectionsHumansMaleMass ScreeningMiddle AgedPrevalenceRetrospective Studiesblood donationlinkage to caresub-Saharan Africatransfusion-transmitted infections (TTIs)

Identifiers

PMID30712273
PMCPMC6563112

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.