Evidence map›Paper›PMID 30712266›Full record

ArticleClinical and experimental immunology2019

Presence of intragraft B cells during acute renal allograft rejection is accompanied by changes in peripheral blood B cell subsets.

S Heidt, M Vergunst, J D H Anholts, G M J S Swings, E M J Gielis, K E Groeneweg, M J Witkamp, J W de Fijter, M E J Reinders, D L Roelen and 2 more

Abstract readComparative Study
In one paragraph

Article in Clinical and experimental immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Characteristic changes in blood routine and peripheral blood lymphocyte subpopulations in recipients of different types of rejection.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Article
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

S HeidtDepartment of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-6700-188X
M VergunstDepartment of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
J D H AnholtsDepartment of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
G M J S SwingsDepartment of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
E M J GielisDepartment of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
K E GroenewegDepartment of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, the Netherlands.
M J WitkampDepartment of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
J W de FijterDepartment of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, the Netherlands.
M E J ReindersDepartment of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, the Netherlands.
D L RoelenDepartment of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
M EikmansDepartment of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
F H J ClaasDepartment of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

B cells have various functions, besides being plasma cell precursors. We determined the presence of intragraft B cells at time of acute rejection (AR) and looked for correlates of B cell involvement in peripheral blood. Renal biopsies at time of AR or stable graft function were analysed for the presence of B cells and B cell-related gene expression, as well as C4d staining. Peripheral blood B cell subset distribution was analysed at various time-points in patients with AR and controls, alongside serum human leucocyte antigen (HLA) antibodies. AR was accompanied by intragraft CD20

Indexed as

Kidney TransplantationAcute DiseaseAdultAgedAntigens, CD20Blood CirculationB-LymphocytesCell MovementChemokine CXCL13FemaleGraft RejectionGraft SurvivalHumansImmunologic MemoryIsoantibodiesKidneyAntigens, CD20Chemokine CXCL13IsoantibodiesB cell infiltrationflow cytometrymemory B cellT cell/B cell interaction

Identifiers

PMID30712266
PMCPMC6514375

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.