ArticleActa psychiatrica Scandinavica2019
Medication adherence in first episode psychosis: the role of pre-onset subthreshold symptoms.
Article in Acta psychiatrica Scandinavica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Treatment Adherence and Health Care Utilization After a First Episode of Psychosis.JAMA network open · 2026Article
- Perceived Changes, Acceptability, and Preliminary Outcomes Associated with a Nurse-Led Medication Adherence Support Program for Patients with First-Episode Psychosis and Their Families: A Pilot Study.Community mental health journal · 2026Article
- Subcategories of the Clinical High-Risk State for Psychosis and Their Relationship to a Full First-Episode Psychosis Sample: An Exploratory Analysis of Longitudinal Outcomes.Schizophrenia bulletin · 2026Article
- Schizophrenia Following Early Adolescence Prodrome: A Neurodevelopmental Subtype With Autism-like Sensorimotor and Social Cognition Deficits.Schizophrenia bulletin · 2025Article
- Subtyping first-episode psychosis based on longitudinal symptom trajectories using machine learning.Npj mental health research · 2025Article
- Engaging with care in an early intervention for psychosis program: The role of language, communication, and culture.Transcultural psychiatry · 2025Article
- Sex differences in outcomes of first episode psychosis: results from an early intervention service.Frontiers in behavioral neuroscience · 2025Article
- Combinations and Temporal Associations Among Precursor Symptoms Before a First Episode of Psychosis.Schizophrenia bulletin · 2024Article
- Influencing factors of medication adherence in schizophrenic patients: a meta-analysis.Schizophrenia (Heidelberg, Germany) · 2023Article
- Article
- Improving the Detection of Individuals at Clinical Risk for Psychosis in the Community, Primary and Secondary Care: An Integrated Evidence-Based Approach.Frontiers in psychiatry · 2019Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe experience of pre-onset subthreshold psychotic symptoms (STPS, signifying a clinical high-risk state) in first episode psychosis (FEP) predicts poorer outcomes during treatment, possibly through differential adherence to medication. We explored whether adherence differs between FEP patients with and without pre-onset STPS.
methodsAntipsychotic medication adherence was compared in 263 STPS+ and 158 STPS- subjects in a specialized early intervention program for FEP. Data were gathered from a larger observational study conducted between 2003 and 2016. STPS status, sociodemographic, and baseline clinical variables were tested as predictors of non-adherence using univariate and multivariate logistic regressions. Time to onset of non-adherence was analyzed using Kaplan-Meier curves. The same predictors were tested as predictors of time to onset of non-adherence using Cox regression models.
resultsMedication non-adherence was higher in STPS+ participants (78.9% vs. 68.9%). STPS status (OR 1.709), substance use disorder (OR 1.767), and milder positive symptoms (OR 0.972) were significant baseline predictors of non-adherence. Substance use disorder (HR 1.410), milder positive symptoms (HR 0.990), and lack of contact between the clinical team and relatives (HR 1.356) were significant baseline predictors of time to non-adherence.
conclusionFEP patients who experience pre-onset STPS are more likely to be non-adherent to antipsychotic medication over 2 years of intervention. FEP programs should routinely evaluate pre-onset symptomatology to deliver more personalized treatments, with emphasis on engaging both patients and family members from the beginning of care.
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