Evidence map›Paper›PMID 30712191›Full record

ArticlePathology oncology research : POR2020

miR-370 Sensitizes TMZ Response Dependent of MGMT Status in Primary Central Nervous System Lymphoma.

Xinwei Li, Xueying Xu, Keng Chen, Haijian Wu, Yirong Wang, Shuxu Yang, Kun Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathology oncology research : POR, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xinwei LiDepartment of Neurosurgery, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou, 310016, People's Republic of China.
Xueying XuDepartment of Neurosurgery, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou, 310016, People's Republic of China.
Keng ChenDepartment of Neurosurgery, Hangzhou Xiasha Hospital, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou, 310016, People's Republic of China.
Haijian WuDepartment of Neurosurgery, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou, 310016, People's Republic of China.
Yirong WangDepartment of Neurosurgery, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou, 310016, People's Republic of China.
Shuxu YangDepartment of Neurosurgery, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou, 310016, People's Republic of China.
Kun WangDepartment of Neurosurgery, Hangzhou Xiasha Hospital, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou, 310016, People's Republic of China. simonkunwang@zju.edu.cn.ORCID http://orcid.org/0000-0001-6819-7661
Sir Run Run Shaw Hospital · CN

Funding

Medicine and Health Science and Technology Projects of Zhejiang Province 2018270408National Natural Science Foundation of China 81402044Natural Science Foundation of Zhejiang Province of China LY14H160017Natural Science Foundation of Zhejiang Province of China LY14H160025Program for Health and Family Planning Commission of Hangzhou Municipality 2017A73Program for Science and Technology Department of Zhejiang Province 2015C33217
6 · The paper itself

Abstract

Primary central nervous system lymphoma (PCNSL) is an aggressive and rare subtype of non-Hodgkin lymphoma, arising exclusively in the CNS with a poor prognosis. Previous evidence has proved that MGMT was a promising target involving in TMZ resistance of PCNSL. Our study described a new miR-370-mediated mechanism of MGMT regulation in PCNSL. We first showed that miR-370 was downregulated in PCNSL tissues, while MGMT was inversely overexpressed. It was also observed that miR-370 suppressed the expression of MGMT. Additionally, upregulation of miR-370 significantly increased TMZ sensitivity dependent of MGMT, thus suppressed Raji cell proliferation and induced apoptosis in vitro. In conclusion, these results suggest that miR-370 is a potential target in PCNSL treatment.

Indexed as

Central Nervous System NeoplasmsLymphoma, Non-HodgkinAntineoplastic Agents, AlkylatingDNA Modification MethylasesDNA Repair EnzymesDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticHumansMicroRNAsTemozolomideTumor Suppressor ProteinsAntineoplastic Agents, AlkylatingDNA Modification MethylasesDNA Repair EnzymesMGMT protein, humanMicroRNAsMIRN370 microRNA, humanTemozolomideTumor Suppressor ProteinsDrug resistanceMGMTmiR-370Primary central nervous system lymphomaTemozolomide

Identifiers

PMID30712191
PMCPMC7242252
OpenAlexW2913974404

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.