Evidence map›Paper›PMID 30712085›Full record

ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2019

Substrate promiscuity and active site differences in gentisate 1,2-dioxygenases: electron paramagnetic resonance study.

Aleksey Aleshintsev, Erik Eppinger, Janosch A D Gröning, Andreas Stolz, Rupal Gupta

Abstract read
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In one paragraph

Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Aleksey AleshintsevDepartment of Chemistry and Biochemistry, College of Staten Island, City University of New York, 2800 Victory Blvd., Staten Island, New York, 10314, USA.
Erik EppingerInstitut für Mikrobiologie, Universität Stuttgart, Allmandring 31, 70569, Stuttgart, Germany.
Janosch A D GröningInstitut für Mikrobiologie, Universität Stuttgart, Allmandring 31, 70569, Stuttgart, Germany.
Andreas StolzInstitut für Mikrobiologie, Universität Stuttgart, Allmandring 31, 70569, Stuttgart, Germany.
Rupal GuptaDepartment of Chemistry and Biochemistry, College of Staten Island, City University of New York, 2800 Victory Blvd., Staten Island, New York, 10314, USA. rupal.gupta@csi.cuny.edu.ORCID 0000-0001-8637-6129
University of Stuttgart · DEThe Graduate Center, CUNY · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gentisate 1,2-dioxygenases (GDOs) are non-heme iron enzymes that catalyze the oxidation of dihydroxylated aromatic substrate, gentisate (2,5-dihydroxybenzoate). Salicylate 1,2-dioxygenase (SDO), a member of the GDO family, performs the ring scission of monohydroxylated substrates such as salicylate, thereby oxidizing a broader range of substrates compared to GDOs. Although the two types of enzymes share a high degree of sequence similarity, the origin of substrate specificity between SDO and GDOs is not understood. We present electron paramagnetic resonance (EPR) investigation of ferrous-nitrosyl complexes of SDO and a GDO from the bacterium Corynebacterium glutamicum (GDO

Indexed as

BiocatalysisCatalytic DomainCorynebacterium glutamicumDioxygenasesElectron Spin Resonance SpectroscopySubstrate SpecificityDioxygenasesgentisate 1,2-dioxygenaseEPRGentisate dioxygenaseIron-nitrosyl complexNon-heme dioxygenasesSalicylate dioxygenase

Identifiers

PMID30712085
OpenAlexW2914301069

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.