Evidence map›Paper›PMID 30711745›Full record

ReviewCurrent opinion in microbiology2019

Vibrio variations on a type three theme.

Kelly A Miller, Katharine F Tomberlin, Michelle Dziejman

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Exploring Mobile Genetic Elements in Vibrio cholerae.Genome biology and evolution · 2025
    Article
  6. Article
  7. Article
  8. VopX, a novelmBio · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Non-O1/Non-O139Microorganisms · 2024
    Review
  13. Microbial genomics · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Genetic Basis of High-Pressure Tolerance of aFrontiers in microbiology · 2022
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kelly A MillerDepartment of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States.
Katharine F TomberlinDepartment of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States.
Michelle DziejmanDepartment of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States. Electronic address: michelle_dziejman@urmc.rochester.edu.
University of Rochester · US

Funding

Novel effector protein functions encoded by T3SS positive V. choleraeR01AI126005 · NIAID · UNIVERSITY OF ROCHESTER · PI DZIEJMAN, MICHELLE · 2017 to 2021
$2.4M
NIAID NIH HHS R01 AI126005
6 · The paper itself

Abstract

Mounting evidence suggests that Type 3 Secretion Systems (T3SS) are widespread among Vibrio species, and are present in strains isolated from diverse sources such as human clinical infections, environmental reservoirs, and diseased marine life. Experiments evaluating Vibrio parahaemolyticus and Vibrio cholerae T3SS mediated virulence suggest that Vibrio T3SS pathogenicity islands have a tripartite composition. A conserved 'core' region encodes functions essential for colonization and disease in vivo, including modulation of innate immune signaling pathways and actin dynamics, whereas regions flanking core sequences are variable among strains and encode effector proteins performing a diverse array of activities. Characterizing novel functions associated with Vibrio-specific effectors is, therefore, essential for understanding how vibrios employ T3SS mechanisms to cause disease in a broad range of hosts and how T3SS island composition potentially defines species-specific disease.

Indexed as

Host-Pathogen InteractionsAnimalsHumansImmune EvasionType III Secretion SystemsVibrio choleraeVibrio parahaemolyticusVirulenceVirulence FactorsType III Secretion SystemsVirulence Factors

Identifiers

PMID30711745
PMCPMC6541499
OpenAlexW2914940841

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.