ArticleNeuroImage. Clinical2019
Mapping acute lesion locations to physiological swallow impairments after stroke.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05603377 (Neuro Anatomical Correlation of Oropharyngeal Swallowing Revisited in Cerebrovascular Stroke Patients), which is not on this map. Cited by 62 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neuro Anatomical Correlation of Oropharyngeal Swallowing Revisited in Cerebrovascular Stroke Patients
Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Role of White Matter in the Neural Control of Swallowing: A Systematic Review.Frontiers in human neuroscience · 2021Pooled it
- Effect of transcranial direct current stimulation on swallowing improvement and cortical activity in hemispheric stroke patients: a randomized, controlled trial.Scientific reports · 2025Trial
- Trial
- Trial
- SimulScan and Partial Least Squares: Visualizing Swallowing Through Functional and Dynamic Imaging Correlations.Magnetic resonance in medicine · 2026Article
- Upward Effortful Pitch Glide as a Predictor of Pharyngeal Constriction in Individuals With Upper Versus Lower Motor Neuron Lesions.American journal of speech-language pathology · 2026Article
- Symptom Network and Lesion Mapping of Post-Stroke Depression, Cognitive Impairment, and Dysfunction: A Multicenter Cohort Study.Brain and behavior · 2026Observational
- Association of Coexisting Low Tongue Pressure and Sarcopenia with Pharyngeal Residue in Older Adults with Presbyphagia.Dysphagia · 2026Article
- Construction of a Risk Prediction Model of Swallowing Dysfunction During Recovery from Acute Ischemic Stroke.Healthcare (Basel, Switzerland) · 2026Article
- Article
- White Matter Structural Biomarkers Derived from Diffusion Tensor Imaging to Estimate Upper-Extremity Motor Function in Stroke Using Machine Learning.Brain topography · 2026Article
- Cortical Activation and Functional Connectivity Changes during Swallowing in Patients with Dysphagia in Lateral Medullary Syndrome.Dysphagia · 2026Article
- Machine learning for dysphagia risk prediction in older adults after acute ischemic stroke.BMC medical informatics and decision making · 2026Article
- Article
- Multimodal deep learning outperforms clinical and brain region models in predicting stroke-associated pneumonia: an explainable AI study.Frontiers in neurology · 2026Article
- Post-stroke dysphagia across the care continuum: a full-cycle framework for rehabilitation, supportive care, and community follow-up.Frontiers in neurology · 2026Review
- SimulScan and Partial Least Squares: Visualizing swallowing through functional and dynamic imaging correlations.bioRxiv : the preprint server for biology · 2025Article
- Diffusion Tensor Tractography Studies for Causes of Dysphagia After Stroke: A Systematic Review.Brain sciences · 2025Review
- Impact of bilateral and unilateral cerebral lesions on swallowing recovery at 6 months in poststroke dysphagia.Scientific reports · 2025Article
- Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Dysphagia is a common deficit after a stroke, and it is frequently associated with pneumonia, malnutrition, dehydration, and poor quality of life. It is not yet fully clear which brain regions are directly related to swallowing, and how lesions affect swallow physiology. This study aimed to assess the statistical relationship between acute stroke lesion locations and impairment of specific aspects of swallow physiology. We performed lesion symptom mapping with 68 retrospectively recruited, acute, first-ever ischemic stroke patients. Lesions were determined on diffusion weighted MRI scans. Post-stroke swallow physiology was determined using the Modified Barium Swallow Study Impairment Profile (MBSImP©™). The relationship between brain lesion location and 17 physiological aspects of swallowing were tested using voxel-based and region-based statistical associations corrected for multiple comparisons using permutation thresholding. We found that laryngeal elevation, anterior hyoid excursion, laryngeal vestibular closure, and pharyngeal residue were associated with lesioned voxels or regions of interests. All components showed distinct and overlapping lesion locations, mostly in the right hemisphere, and including cortical regions (inferior frontal gyrus, pre- and postcentral gyrus, supramarginal gyrus, angular gyrus, superior temporal gyrus, insula), subcortical regions (thalamus, amygdala) and white matter tracts (superior longitudinal fasciculus, corona radiata, internal capsule, external capsule, ansa lenticularis, lenticular fasciculus). Our findings indicate that different aspects of post-stroke swallow physiology are associated with distinct lesion locations, primarily in the right hemisphere, and primarily including sensory-motor integration areas and their corresponding white matter tracts. Future studies are needed to expand on our findings and thus, support the development of a neuroanatomical model of post-stroke swallow physiology and treatment approaches targeting the neurophysiological underpinnings of swallowing post stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.