ArticleNeuroImage. Clinical2019
Functional correlates of strategy formation and verbal suppression in Parkinson's disease.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cerebellar Contribution to Motor and Non-motor Functions in Parkinson's Disease: A Meta-Analysis of fMRI Findings.Frontiers in neurology · 2020Pooled it
- Exploring brain asymmetry in early-stage Parkinson's disease through functional and structural MRI.CNS neuroscience & therapeutics · 2024Article
- Semantic fluency deficits and associated brain activity in Parkinson's disease with mild cognitive impairment.Brain imaging and behavior · 2022Article
- Does Prefrontal Glutamate Index Cognitive Changes in Parkinson's Disease?Frontiers in human neuroscience · 2022Article
- The Role of Cortico-Thalamo-Cortical Circuits in Language: Recurrent Circuits Revisited.Neuropsychology review · 2021Review
- Corticostriatal Regulation of Language Functions.Neuropsychology review · 2021Review
- From discourse to pathology: Automatic identification of Parkinson's disease patients via morphological measures across three languages.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individuals with Parkinson's disease (PD) have shown impaired performance on the verbal suppression component of the Haylings Sentence Completion Test (HSCT). The present study aimed to determine whether this performance related to (i) the inability to suppress a pre-potent response or (ii) difficulty in the generation of a strategy to facilitate task execution. The study adopted a novel variation of the HSCT that isolated each process and employed fMRI to examine the associated neural correlates in a comparison of individuals with PD and matched healthy controls. No significant behavioral differences were detected between these two groups. However, fMRI results revealed atypical underlying neural activity in the PD group. Controls exhibited increased activation in the left dorsolateral prefrontal cortex and striatum when generating a response independently, relative to generation when a supporting strategy was provided. The PD group demonstrated the opposite pattern of activation, in addition to greater recruitment of right hemisphere regions. This pattern of activation was postulated to be evidence of compensatory mechanisms, acting to bolster the output of frontostriatal circuits compromised by disease pathology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.