ArticleExperimental neurology2019
Mild blast-related TBI in a mouse model alters amygdalar neurostructure and circuitry.
Article in Experimental neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Post-traumatic stress disorder: pathogenesis, epidemiological characteristics, animal models, and potential therapeutic strategies.Military Medical Research · 2026Review
- The link between impact-induced tensile strain and dendritic spine morphology in porcine brain tissue.PloS one · 2025Article
- Low-Intensity Blast Exposure Induces Multifaceted Long-Lasting Anxiety-Related Behaviors in Mice.Neurotrauma reports · 2024Article
- Volumetric MRI Findings in Mild Traumatic Brain Injury (mTBI) and Neuropsychological Outcome.Neuropsychology review · 2023Review
- GABAergic circuits of the basolateral amygdala and generation of anxiety after traumatic brain injury.Amino acids · 2022Review
- Brain Injury Effects on Neuronal Activation and Synaptic Transmission in the Basolateral Amygdala of Adult Male and Female Wistar Rats.Journal of neurotrauma · 2022Article
- Long-Term Effects of Low-Intensity Blast Non-Inertial Brain Injury on Anxiety-Like Behaviors in Mice: Home-Cage Monitoring Assessments.Neurotrauma reports · 2022Article
- Limbic Responses Following Shock Wave Exposure in Male and Female Mice.Frontiers in behavioral neuroscience · 2022Article
- Roadmap for Advancing Pre-Clinical Science in Traumatic Brain Injury.Journal of neurotrauma · 2021Review
- Reaction-Diffusion Model-Based Research on Formation Mechanism of Neuron Dendritic Spine Patterns.Frontiers in neurorobotics · 2021Article
- A Role for the Amygdala in Impairments of Affective Behaviors Following Mild Traumatic Brain Injury.Frontiers in behavioral neuroscience · 2021Review
- Multi-sensory (auditory and somatosensory) pre-pulse inhibition in mice.Physiology & behavior · 2020Article
- Effect of mild blast-induced TBI on dendritic architecture of the cortex and hippocampus in the mouse.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Traumatic brain injury (TBI) continues to be a signature injury of our modern conflicts. Due in part to increased use of improvised explosive devices (IEDs), we have seen blast trauma make up a significant portion of TBIs sustained by deployed troops and civilians. In addition to the physical injury, TBI is also a common comorbidity with post-traumatic stress disorder (PTSD). Previous research suggests that PTSD is often associated with increased signaling within the amygdala, leading to feelings of fear and hyperarousal. In our study, we utilized a mouse model of mild blast-related TBI (bTBI) to investigate how TBI induces changes within the amygdala, which may provide favorable conditions for the development of PTSD. To do this, we performed Golgi staining on the stellate neurons of the basolateral amygdala and quantified dendritic amount, distribution, and complexity. We found increases in dendritic branching and in the density of dendritic spines in injured mice. Increases in spine density appears to be primarily due to increases in memory associated mushroom type dendritic spines. These changes observed in our bTBI model that are consistent with chronic stress models, suggesting an important connection between the physical changes induced by TBI and the neurological symptoms of PTSD.
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