Evidence map›Paper›PMID 30711631›Full record

ArticleJournal of pain and symptom management2019

Circadian Rhythmicity as a Predictor of Quality of Life in Allogeneic Hematopoietic Cell Transplant Patients.

Aasha I Hoogland, Hailey W Bulls, Brian D Gonzalez, Brent J Small, Lianqi Liu, Joseph Pidala, Heather S L Jim, Asmita Mishra

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pain and symptom management, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Aasha I HooglandDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida, USA.
Hailey W BullsDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida, USA.
Brian D GonzalezDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida, USA.
Brent J SmallSchool of Aging Studies, University of South Florida, Tampa, Florida, USA.
Lianqi LiuDepartment of Psychiatry, University of California, San Diego, La Jolla, California, USA.
Joseph PidalaDepartment of Blood and Marrow Transplantation and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, Florida, USA.
Heather S L JimDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida, USA.
Asmita MishraDepartment of Blood and Marrow Transplantation and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, Florida, USA. Electronic address: asmita.mishra@moffitt.org.
Moffitt Cancer Center · USUniversity of California San Diego · USUniversity of South Florida · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
Behavioral Oncology Education & Career DevelopmentR25CA090314 · NCI · H. LEE MOFFITT CANCER CTR &RES INST · PI BRANDON, THOMAS H · 2003 to 2018
$4.0M
NCI NIH HHS P30 CA076292NCI NIH HHS R25 CA090314
6 · The paper itself

Abstract

contextQuality of life (QoL) is increasingly recognized as an important outcome of cancer treatment. Previous studies have examined clinical predictors of QoL, but with the increasing prevalence of wearable sensors that monitor sleep and activity patterns, further investigation into whether these behaviors are predictive of post-treatment QoL is now feasible. Among patients receiving aggressive cancer treatment such as hematopoietic cell transplantation (HCT), analysis of circadian rhythms (24-hour patterns of sleep and activity) via wearable sensors is limited.

objectiveTo evaluate the relationship between overall QoL and circadian rhythms in patients receiving allogeneic HCT.

methodsPatients wore an ActiGraph GT3X (Pensacola, FL) activity monitor for at least 72 hours before the initiation of conditioning chemotherapy and transplantation and completed a QoL (Functional Assessment of Cancer Therapy-General [FACT-G]) assessment. QoL assessments were also completed 1, 3, and 6 months after HCT.

resultsPatients (n = 45, M age = 55) were mostly male (66%) with a total FACT-G score of 80.96 (SD = 16.05) before HCT. Mixed models revealed robust cross-sectional associations between overall QoL and multiple circadian rhythmicity parameters, including durations of high physical activity, overall circadian rhythmicity, and earlier starts of daily activity (P's < .01). Recovery of QoL after transplant was predicted by longer pre-transplant durations of high physical activity (P = .04) and earlier evening retirement (P = .04).

conclusionOur findings suggest that wearable sensor information is a promising method of predicting recovery of QoL after HCT. Additional studies are needed to confirm these findings in a larger sample.

Indexed as

Circadian RhythmHematopoietic Stem Cell TransplantationQuality of LifeActigraphyFemaleHumansLongitudinal StudiesMaleMiddle AgedMotor ActivityNeoplasmsPilot ProjectsPrognosisTransplantation, HomologousTreatment Outcomecircadian rhythmsHCTQuality of lifewearable devices

Identifiers

PMID30711631
PMCPMC6486418
OpenAlexW2911433646

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.