Evidence map›Paper›PMID 30711534›Full record

ArticleToxicology and applied pharmacology2019

Maternal titanium dioxide nanomaterial inhalation exposure compromises placental hemodynamics.

Alaeddin B Abukabda, Elizabeth C Bowdridge, Carroll R McBride, Thomas P Batchelor, William T Goldsmith, Krista L Garner, Sherri Friend, Timothy R Nurkiewicz

Abstract read
In one paragraph

Article in Toxicology and applied pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Article
  3. Current approaches and advances in placental toxicology.Trends in endocrinology and metabolism: TEM · 2026
    Review
  4. Review
  5. Therapeutic nanoparticle safety in pregnancy: Bridging knowledge gaps with environmental insights and a translational roadmap.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Nanomaterial Inhalation During Pregnancy Alters Systemic Vascular Function in a Cyclooxygenase-Dependent Manner.Toxicological sciences : an official journal of the Society of Toxicology · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alaeddin B AbukabdaDepartment of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, USA; Toxicology Working Group, West Virginia University School of Medicine, Morgantown, WV, USA.
Elizabeth C BowdridgeDepartment of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, USA; Toxicology Working Group, West Virginia University School of Medicine, Morgantown, WV, USA.
Carroll R McBrideDepartment of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, USA; Toxicology Working Group, West Virginia University School of Medicine, Morgantown, WV, USA.
Thomas P BatchelorDepartment of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, USA; Toxicology Working Group, West Virginia University School of Medicine, Morgantown, WV, USA.
William T GoldsmithDepartment of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, USA; Toxicology Working Group, West Virginia University School of Medicine, Morgantown, WV, USA.
Krista L GarnerDepartment of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, USA; Toxicology Working Group, West Virginia University School of Medicine, Morgantown, WV, USA.
Sherri FriendNational Institute for Occupational Safety and Health, Morgantown, WV, USA.
Timothy R NurkiewiczDepartment of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, USA; Toxicology Working Group, West Virginia University School of Medicine, Morgantown, WV, USA; National Institute for Occupational Safety and Health, Morgantown, WV, USA. Electronic address: tnurkiewicz@hsc.wvu.edu.

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Sally Lynn Hodder · 2012 to 2026
$81.0M
Remote Microvascular Dysfunction After Particulate Matter ExposureR01ES015022 · NIEHS · WEST VIRGINIA UNIVERSITY · PI NURKIEWICZ, TIMOTHY R · 2007 to 2021
$4.9M
NIEHS NIH HHS R01 ES015022NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

The fetal consequences of gestational engineered nanomaterial (ENM) exposure are unclear. The placenta is a barrier protecting the fetus and allowing transfer of substances from the maternal circulation. The purpose of this study was to determine the effects of maternal pulmonary titanium dioxide nanoparticle (nano-TiO

Indexed as

AnimalsFemaleHemodynamicsInhalation ExposureMaternal ExposureMetal NanoparticlesPlacentaPregnancyRats, Sprague-DawleyTitaniumTitaniumtitanium dioxideEngineered nanomaterialsMicrocirculationPlacentaTitanium dioxide nanoparticles

Identifiers

PMID30711534
PMCPMC6422339

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.