Evidence map›Paper›PMID 30711483›Full record

ArticleNeurobiology of disease2019

Mannitol decreases neocortical epileptiform activity during early brain development via cotransport of chloride and water.

J Glykys, E Duquette, N Rahmati, K Duquette, K J Staley

Open access · greenAbstract read
In one paragraph

Article in Neurobiology of disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Unique Actions of GABA Arising from Cytoplasmic Chloride Microdomains.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. CurrentCurrent opinion in biomedical engineering · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

J GlykysDepartment of Neurology, Massachusetts General Hospital, Boston 02114, United States; Harvard Medical School, Boston, MA 02115, United States. Electronic address: joseph-glykys@uiowa.edu.
E DuquetteDepartment of Neurology, Massachusetts General Hospital, Boston 02114, United States.
N RahmatiDepartment of Neurology, Massachusetts General Hospital, Boston 02114, United States; Harvard Medical School, Boston, MA 02115, United States.
K DuquetteDepartment of Neurology, Massachusetts General Hospital, Boston 02114, United States; Northeastern University, Boston 02115, United States.
K J StaleyDepartment of Neurology, Massachusetts General Hospital, Boston 02114, United States; Harvard Medical School, Boston, MA 02115, United States.
Harvard University · USMassachusetts General Hospital · USNortheastern University · US

Funding

Neuronal Chloride distribution by displacementR01NS040109 · NINDS · UNIVERSITY OF COLORADO DENVER · PI STALEY, KEVIN J. · 2000 to 2020
$7.2M
Osmotic Therapy for Seizures in Pediatric Traumatic Brain InjuryK08NS091248 · NINDS · UNIVERSITY OF IOWA · PI GLYKYS, JOSEPH C. · 2015 to 2019
$978k
NINDS NIH HHS K08 NS091248NINDS NIH HHS R01 NS040109
6 · The paper itself

Abstract

Seizures and brain injury lead to water and Cl

Indexed as

AnimalsAnimals, NewbornChloridesDiuretics, OsmoticFemaleMaleMannitolMiceMice, Inbred C57BLNeocortexNeuronsSeizuresSodium Chloride SymportersSynaptic TransmissionWaterChloridesDiuretics, OsmoticMannitolSodium Chloride SymportersWaterChlorideCytotoxic edemaDevelopmentGABA transmissionMannitolNeocortexSeizuresWater

Identifiers

PMID30711483
PMCPMC6459411
OpenAlexW2911545475

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.