Evidence map›Paper›PMID 30711208›Full record

ReviewGastroenterology clinics of North America2019

Nonceliac Wheat Sensitivity: An Immune-Mediated Condition with Systemic Manifestations.

Umberto Volta, Roberto De Giorgio, Giacomo Caio, Melanie Uhde, Roberto Manfredini, Armin Alaedini

Registry-linked trialAbstract readReview
In one paragraph

Review in Gastroenterology clinics of North America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04377061 (Clinical Characteristics and Pathogenic Mechanisms of Anemia in Non-celiac Wheat Sensitivity Compared to Celiac Disease and Irritable Bowel Syndrome), which is not on this map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04377061 completednot on this mapstarted 2020, after this paper: background citation

Clinical Characteristics and Pathogenic Mechanisms of Anemia in Non-celiac Wheat Sensitivity Compared to Celiac Disease and Irritable Bowel Syndrome

TypeobservationalSponsorUniversity of PalermoRan2020 to 2022Enrolled244ConditionsNon-celiac Gluten Sensitivity, AnemiaArmsEvaluation of anemia
3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Wheat-Related Gastrointestinal Diseases: Narrative Review.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Celiac Disease Revisited.GE Portuguese journal of gastroenterology · 2022
    Review
  17. Article
  18. Review
  19. Non-Celiac Gluten Sensitivity: An Update.Medicina (Kaunas, Lithuania) · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Umberto VoltaDepartment of Medical and Surgical Sciences, St. Orsola-Malpighi Hospital, University of Bologna, Via Zamboni, 33, Bologna BO 40126, Italy.
Roberto De GiorgioDepartment of Medical Sciences, Nuovo Arcispedale St. Anna in Cona, University of Ferrara, Via Savonarola, 9, Ferrara FE 44121, Italy.
Giacomo CaioDepartment of Medical and Surgical Sciences, St. Orsola-Malpighi Hospital, University of Bologna, Via Zamboni, 33, Bologna BO 40126, Italy; Mucosal Immunology and Biology Research Center, Building 114 16th Street, Charlestown, MA 02129, USA.
Melanie UhdeDepartment of Medicine, Columbia University Medical Center, 1130 Saint Nicholas Avenue, New York, NY 10032, USA; Celiac Disease Center, Columbia University Medical Center, 180 Fort Washington Avenue, New York, NY 10032, USA.
Roberto ManfrediniDepartment of Medical Sciences, Nuovo Arcispedale St. Anna in Cona, University of Ferrara, Via Savonarola, 9, Ferrara FE 44121, Italy.
Armin AlaediniDepartment of Medicine, Columbia University Medical Center, 1130 Saint Nicholas Avenue, New York, NY 10032, USA; Celiac Disease Center, Columbia University Medical Center, 180 Fort Washington Avenue, New York, NY 10032, USA; Institute of Human Nutrition, Columbia University Medical Center, 630 West 168(th) Street, New York, NY 10032, USA. Electronic address: aa819@columbia.edu.

Funding

Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
NCATS NIH HHS UL1 TR000040
6 · The paper itself

Abstract

Non-celiac wheat sensitivity (NCWS) is characterized by gastrointestinal and extra-intestinal symptoms following the ingestion of gluten-containing cereals in subjects without celiac disease or wheat allergy. The identity of the molecular triggers in these cereals responsible for the symptoms of NCWS remains to be delineated. Recent research has identified a biological basis for the condition, with the observation of systemic immune activation in response to microbial translocation that appears to be linked to intestinal barrier defects. Ongoing research efforts are aimed at further characterizing the etiology, mechanism, and biomarkers of the condition.

Indexed as

Adaptive ImmunityAdultCeliac DiseaseDiet, Gluten-FreeFemaleGastrointestinal MicrobiomeHumansImmunity, InnateIntestinal MucosaMaleMiddle AgedWheat HypersensitivityAmylase/protease inhibitorAntibody to native gliadinBiomarkersFructanGlutenIntestinal barrier functionSystemic immune activationWheat

Identifiers

PMID30711208
PMCPMC6364564

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.