ArticleBiological psychiatry2019
Hyperperfusion of Frontal White and Subcortical Gray Matter in Autism Spectrum Disorder.
Article in Biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Sex/gender differences in the human autistic brains: A systematic review of 20 years of neuroimaging research.NeuroImage. Clinical · 2021Pooled it
- Brain-based sex differences in autism spectrum disorder across the lifespan: A systematic review of structural MRI, fMRI, and DTI findings.NeuroImage. Clinical · 2021Pooled it
- Effect of post-labeling delay on regional cerebral blood flow in arterial spin-labeling MR imaging.Medicine · 2020Trial
- Evaluation of Brain Microstructural Alterations in Preschool Autism Spectrum Disorder: A Voxel-Wise Multimodal MRI Study.Journal of magnetic resonance imaging : JMRI · 2026Article
- Reviewing vascular influences on neuronal migration, cortical development, and neurodevelopmental disorders: focus on autism, ADHD and schizophrenia.Molecular psychiatry · 2025Review
- Biophysically constrained dynamical modelling of the brain using multimodal magnetic resonance imaging.Brain research bulletin · 2025Article
- Investigating cerebral blood flow dysregulation and serum zinc correlation in 2-4 year-old children with autism spectrum disorder.European journal of medical research · 2025Article
- Associations of Maternal Prenatal Zinc Consumption with Infant Brain Tissue Organization and Neurodevelopmental Outcomes.Nutrients · 2025Article
- [Neurodevelopment and cerebral blood flow in children aged 2-6 years with autism spectrum disorder].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Sex, hormones and cerebrovascular function: from development to disorder.Fluids and barriers of the CNS · 2024Review
- Corrigendum: Neurovascular crosstalk and cerebrovascular alterations: an underestimated therapeutic target in autism spectrum disorders.Frontiers in cellular neuroscience · 2024Article
- Modelling the overlap and divergence of autistic and schizotypal traits on hippocampal subfield volumes and regional cerebral blood flow.Molecular psychiatry · 2024Article
- Application of Multimodal MRI in the Early Diagnosis of Autism Spectrum Disorders: A Review.Diagnostics (Basel, Switzerland) · 2023Review
- Geometry-derived statistical significance: A probabilistic framework for detecting true positive findings in MRI data.Brain and behavior · 2023Article
- Three-dimensional pseudocontinuous arterial spin labeling perfusion imaging shows cerebral blood flow perfusion decline in attention-deficit/hyperactivity disorder children.Frontiers in psychiatry · 2023Article
- Neurovascular crosstalk and cerebrovascular alterations: an underestimated therapeutic target in autism spectrum disorders.Frontiers in cellular neuroscience · 2023Review
- Associations of Human Milk Oligosaccharides with Infant Brain Tissue Organization and Regional Blood Flow at 1 Month of Age.Nutrients · 2022Article
- Using tissue microstructure and multimodal MRI to parse the phenotypic heterogeneity and cellular basis of autism spectrum disorder.Journal of child psychology and psychiatry, and allied disciplines · 2022Article
- Genome-wide imputed differential expression enrichment analysis identifies trait-relevant tissues.Frontiers in genetics · 2022Article
- Application of Quantitative Magnetic Resonance Imaging in the Diagnosis of Autism in Children.Frontiers in medicine · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundOur aim was to assess resting cerebral blood flow (rCBF) in children and adults with autism spectrum disorder (ASD).
methodsWe acquired pulsed arterial spin labeling magnetic resonance imaging data in 44 generally high-functioning participants with ASD simplex and 66 typically developing control subjects with comparable mean full-scale IQs. We compared rCBF values voxelwise across diagnostic groups and assessed correlations with symptom scores. We also assessed the moderating influences of participant age, sex, and IQ on our findings and the correlations of rCBF with N-acetylaspartate metabolite levels.
resultsWe detected significantly higher rCBF values throughout frontal white matter and subcortical gray matter in participants with ASD. rCBF correlated positively with socialization deficits in participants with ASD in regions where hyperperfusion was greatest. rCBF declined with increasing IQ in the typically developing group, a correlation that was absent in participants with ASD, whose rCBF values were elevated across all IQ levels. rCBF in the ASD group correlated inversely with N-acetylaspartate metabolite levels throughout the frontal white matter, with greater rCBF accompanying lower and increasingly abnormal N-acetylaspartate levels relative to those of typically developing control subjects.
conclusionsThese findings taken together suggest the presence of altered metabolism, likely of mitochondrial origin, and dysfunctional maintenance processes that support axonal functioning in ASD. These disturbances in turn likely reduce neural efficiency for cognitive and social functioning and trigger compensatory responses from supporting glial cells, which subsequently increase rCBF to affected white matter. These findings, if confirmed, suggest cellular and molecular targets for novel therapeutics that address axonal pathology and bolster glial compensatory responses in ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.