Evidence map›Paper›PMID 30710726›Full record

ReviewCellular and molecular gastroenterology and hepatology2019

Neuropods.

Rodger A Liddle

Open access · goldAbstract readReview
In one paragraph

Review in Cellular and molecular gastroenterology and hepatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 54 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Developmental regulation of intestinalbioRxiv : the preprint server for biology · 2025
    Article
  7. Review
  8. Review
  9. Article
  10. Bitter taste receptors as sensors of gut luminal contents.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  11. Review
  12. Intestinal Enteroendocrine Cells: Present and Future Druggable Targets.International journal of molecular sciences · 2023
    Review
  13. Article
  14. Article
  15. Review
  16. A Gut-Centric Model of Metabolic Homeostasis.Journal of diabetes science and technology · 2022
    Article
  17. Review
  18. Article
  19. Review
  20. The Gut-Brain Axis: Two Ways Signaling in Parkinson's Disease.Cellular and molecular neurobiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Rodger A LiddleDuke University Medical Center, Durham Veterans Affairs Health Care System, Durham, North Carolina. Electronic address: rodger.liddle@duke.edu.
Duke Medical Center · US

Funding

The role of gut endocrine cells in Parkinson's DiseaseR01DK109368 · NIDDK · DUKE UNIVERSITY · PI LIDDLE, RODGER A. · 2016 to 2019
$1.4M
Receptor Regulation of CCK Cell FunctionR01DK098796 · NIDDK · DUKE UNIVERSITY · PI LIDDLE, RODGER A. · 2013 to 2016
$1.4M
Gut Neuroendocrine Cell Signaling and ObesityI01BX002230 · VA · DURHAM VA MEDICAL CENTER · PI LIDDLE, RODGER A. · 2014 to 2022
–
BLRD VA I01 BX002230NIDDK NIH HHS R01 DK098796NIDDK NIH HHS R01 DK109368
6 · The paper itself

Abstract

Enteroendocrine cells (EECs) are sensory cells of the gastrointestinal tract. Most EECs reside in the mucosal lining of the stomach or intestine and sense food in the gut lumen. Food signals stimulate the release of hormones into the paracellular space where they either act locally or are taken up into the blood and circulate to distant organs. It recently was recognized that many EECs possess basal processes known as neuropods that not only contain hormones but also connect to nerves. This review describes how neuropods contribute to EEC function beyond typical hormonal actions. For example, gastrointestinal hormones not only act on distant organs, but, through neuropods, some act locally to stimulate other mucosal cells such as intestinal stem cells, enterocytes, or other EECs. With the recent discovery that EECs communicate directly with enteric nerves, EECs not only have the ability to sense food and bacteria in the gastrointestinal tract, but can communicate these signals directly to the nervous system.

Indexed as

AnimalsCell CommunicationEnteroendocrine CellsHumansModels, BiologicalNeuronsParacrine CommunicationSignal TransductionEnteroendocrine cellGut HormoneNeuronNeurotransmissionParacrine

Identifiers

PMID30710726
PMCPMC6463090
OpenAlexW4251823507

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.