ArticleInternational journal of pharmaceutics2019
Storage stability of inhalable phage powders containing lactose at ambient conditions.
Article in International journal of pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Inhalable bacteriophage endolysins: a novel therapeutic strategy for drug-resistant bacterial pulmonary infections - a comprehensive review.Annals of medicine · 2026Review
- Wood Hemicellulose-Based Spray-Dried Microencapsulation of a Lytic Bacteriophage Preserves Phage Viability and Improves Control of the Bacterial Wilt Pathogen Ralstonia solanacearum.Microbial biotechnology · 2026Article
- Latest Advances in Inhalable Dry Powder Bacteriophage Therapy for Pulmonary Infections.Pharmaceutics · 2025Review
- P3MA: A Promising Mycobacteriophage InfectingAntibiotics (Basel, Switzerland) · 2025Article
- Long-term Storage Stability of Inhalable Phage Powder Formulations: A Four-Year Study.The AAPS journal · 2025Article
- Intestinal dysbiosis associated with non-nutritive sweeteners intake: an effect without a cause?Frontiers in nutrition · 2025Review
- Mechanism of bacteriophage-induced vaterite formation.Scientific reports · 2024Article
- Review
- Challenges of bacteriophages application in controlling bacterial plant diseases and how to overcome them.Journal, genetic engineering & biotechnology · 2023Review
- Stability Considerations for Bacteriophages in Liquid Formulations Designed for Nebulization.Cells · 2023Review
- Enhancing the Stability of Bacteriophages Using Physical, Chemical, and Nano-Based Approaches: A Review.Pharmaceutics · 2022Review
- Inhaled Delivery of Anti-Pseudomonal Phages to Tackle Respiratory Infections Caused by Superbugs.Journal of aerosol medicine and pulmonary drug delivery · 2022Review
- Manufacturing Stable Bacteriophage Powders by Including Buffer System in Formulations and Using Thin Film Freeze-drying Technology.Pharmaceutical research · 2021Article
- Article
- Review
- Phage cocktail powder for Pseudomonas aeruginosa respiratory infections.International journal of pharmaceutics · 2021Article
- Bacteriophage-Delivering Hydrogels: Current Progress in Combating Antibiotic Resistant Bacterial Infection.Antibiotics (Basel, Switzerland) · 2021Review
- Prospects of Inhaled Phage Therapy for Combatting Pulmonary Infections.Frontiers in cellular and infection microbiology · 2021Review
- Inhalable bacteriophage powders: Glass transition temperature and bioactivity stabilization.Bioengineering & translational medicine · 2020Article
- Inhalable combination powder formulations of phage and ciprofloxacin for P. aeruginosa respiratory infections.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The aim of this study was to evaluate the storage stability of inhalable phage powders containing lactose and leucine as excipient. As an FDA-approved excipient for inhalation, lactose is preferred over other sugars. PEV phages active against antibiotic-resistant Pseudomonas aeruginosa was spray dried with lactose (55-90%) and leucine (45-10%). Produced powders were heat-sealed in an aluminium pouch at 15% relative humidity (RH) with subsequent storage at 20 °C/60% RH for 12 months. Lactose concentration in the powder positively influenced the phage stability over time. Formulation containing 90% lactose maintained the viability of PEV61 across the study, while ∼1.2 log
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Registered trials
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