ArticleMetabolism: clinical and experimental2019
Core body temperature, energy expenditure, and epinephrine during fasting, eucaloric feeding, and overfeeding in healthy adult men: evidence for a ceiling effect for human thermogenic response to diet.
Article in Metabolism: clinical and experimental, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Cold induces increased ad libitum energy intake independent of changes in energy expenditure: a controlled crossover trial in adults.The American journal of clinical nutrition · 2025Trial
- Combined torso and foot heat exposure reduces acuteTemperature (Austin, Tex.) · 2026Article
- Resting energy expenditure under fasting conditions is primarily explained by fat-free mass rather than cardiac autonomic markers.Frontiers in endocrinology · 2026Article
- Body Temperature, Metabolic, and Circulatory Changes After 8 Days of Water-Only Fasting in Healthy Middle-Aged Men.Journal of clinical medicine · 2025Article
- Global warming and obesity: External heat exposure as a modulator of energy balance.FASEB bioAdvances · 2025Review
- Changes in rectal temperature as a means of assessing heat tolerance and sensitivity in chickens.Tropical animal health and production · 2024Article
- Physical inactivity and breakfast skipping caused visceral fat accumulation in rats.Scientific reports · 2024Article
- Higher central circadian temperature amplitude is associated with greater metabolite rhythmicity in humans.Scientific reports · 2024Article
- Analytical Analysis of Factors Affecting the Accuracy of a Dual-Heat Flux Core Body Temperature Sensor.Sensors (Basel, Switzerland) · 2024Article
- A century of exercise physiology: concepts that ignited the study of human thermoregulation. Part 3: Heat and cold tolerance during exercise.European journal of applied physiology · 2024Review
- A century of exercise physiology: concepts that ignited the study of human thermoregulation. Part 1: Foundational principles and theories of regulation.European journal of applied physiology · 2023Review
- Snack timing affects tissue clock and metabolic responses in male mice.Frontiers in nutrition · 2022Article
- Physiology of Energy Expenditure in the Weight-Reduced State.Obesity (Silver Spring, Md.) · 2021Article
- L-Citrulline Influences the Body Temperature, Heat Shock Response and Nitric Oxide Regeneration of Broilers Under Thermoneutral and Heat Stress Condition.Frontiers in physiology · 2021Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundIn homeothermic animals, approximately 50% of daily energy expenditure (EE) is spent to maintain a consistent core body temperature (CBT). In humans, little is known about CBT responses to feeding and overfeeding and their relationship to diet-related changes in EE.
objectiveTo study the effects of feeding and overfeeding on CBT and its association with diet-induced thermogenesis (DIT).
designFifty-three healthy men with normal glucose regulation and a wide range of body composition (mean ± SD, body fat: 25 ± 8%, range: 7-43%) had 24-h EE assessed during fasting in a whole-room indirect calorimeter with concomitant CBT measurement by ingestible capsules and 24-h urinary collection for catecholamine measurements. Changes in 24-h EE (DIT) and CBT compared to fasting were assessed during three normal-protein (20%) diets using a cross-over design: one eucaloric diet (EBL, 50% carbohydrate, n = 37) and two overfeeding diets with 200% energy requirements: a high-fat (FNP, 60% fat, n = 25) and a high-carbohydrate (CNP; 75% carbohydrate, n = 24) diet.
resultsThe average 24-h CBT (avgCBT) during fasting was 36.81 ± 0.14 °C (inter-individual CV = 0.4%) and positively correlated with 24-h urinary epinephrine (r = 0.61, p < 0.001), but not with body composition measures (p > 0.05). AvgCBT increased during EBL (Δ = 0.06 ± 0.11 °C, p = 0.002), FNP (Δ = 0.13 ± 0.14 °C, p < 0.001), and CNP (Δ = 0.19 ± 0.13 °C, p < 0.001) and associated with increased DIT during EBL (r = 0.43, p = 0.01, β = 31 kcal/day/0.1 °C) and FNP (r = 0.60, p = 0.002, β = 43 kcal/day/0.1 °C), but not CNP (p = 0.47). A ceiling effect for the increase in CBT, but not in DIT, was observed during feeding and, particularly, overfeeding.
conclusionsCBT increases with feeding and is moderately associated with DIT to a different degree depending on the macronutrient composition of the overfeeding diet. There is a ceiling effect such that individuals with a higher CBT during fasting have limited capacity to increase CBT with feeding. Because of body thermoregulatory mechanisms that maintain a constant CBT, these results indicate that CBT has a limited role in the inter-individual variability in DIT.
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