Evidence map›Paper›PMID 30710314›Full record

ArticleSurgical endoscopy2019

Near-infrared fluorescence image-guidance in anastomotic colorectal cancer surgery and its relation to serum markers of anastomotic leakage: a clinical pilot study.

Jacqueline van den Bos, Audrey C H M Jongen, Jarno Melenhorst, Stéphanie O Breukink, Kaatje Lenaerts, Rutger M Schols, Nicole D Bouvy, Laurents P S Stassen

3 registry-linked trialsOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgical endoscopy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04695184 naunknown statusnot on this map

The Value of Subjective Near-infrared Fluorescence Guidance in Assessment of Perfusion During Restorative Ileal Pouch Formation and Ileal-pouch-anal Anastomosis

TypeinterventionalSponsorCharite University, Berlin, GermanyRan2019 to 2021Enrolled50ConditionsUlcerative Colitis, Colorectal Cancer, Crohn Disease, Familial Adenomatous PolyposisArmsICG-NIRF Imaging
NCT04695964 naunknown statusnot on this map

The Value of Objective Perfusion Rate Assessment by Near-infrared Fluorescence During Restorative Ileal Pouch Formation and Ileal-pouch-anal Anastomosis

TypeinterventionalSponsorCharite University, Berlin, GermanyRan2019 to 2021Enrolled50ConditionsUlcerative Colitis, Colorectal Cancer, Crohn Disease, Familial Adenomatous PolyposisArmsICG-NIRF Imaging plus ingress and egress analysis
NCT04709445 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Objective Perfusion Rate Assessment of Gastrointestinal Anastomoses by Inflow and Outflow Analysis of Near-infrared Fluorescence Agents

TypeinterventionalSponsorCharite University, Berlin, GermanyRan2020 to 2021Enrolled100ConditionsBowel Obstruction, Bowel Ischemia, Diverticulitis, Abnormality of the Gastrointestinal TractArmsICG-NIRF Imaging plus ingress and egress analysis
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.

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  19. Risks of anastomotic leakage in patients with colorectal cancer after operation and how to effectively avoid it.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jacqueline van den BosDepartment of Surgery, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands. j.vandenbos@maastrichtuniversity.nl.
Audrey C H M JongenDepartment of Surgery, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands.
Jarno MelenhorstDepartment of Surgery, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands.
Stéphanie O BreukinkDepartment of Surgery, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands.
Kaatje LenaertsDepartment of Surgery, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands.
Rutger M ScholsDepartment of Plastic, Reconstructive and Hand Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.
Nicole D BouvyDepartment of Surgery, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands.
Laurents P S StassenDepartment of Surgery, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands.
Maastricht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveNear-infrared fluorescence (NIRF) imaging using indocyanine green (ICG) might help reduce anastomotic leakage (AL) after colorectal surgery. This pilot study aims to analyze whether a relation exists between measured fluorescence intensity (FI) and postoperative inflammatory markers of AL, C-reactive protein (CRP), Intestinal fatty-acid binding protein (I-FABP), and calprotectin, to AL, in order to evaluate the potential of FI to objectively predict AL.

methodsPatients scheduled for anastomotic colorectal cancer surgery were eligible for inclusion in this prospective pilot study. During surgery, at three time points (after bowel devascularization; before actual transection; after completion of anastomosis) a bolus of 0.2 mg/kg ICG was administered intravenously for assessment of bowel perfusion. FI was scored in scale from 1 to 5 based on the operating surgeon's judgment (1 = no fluorescence visible, 5 = maximum fluorescent signal). The complete surgical procedure was digitally recorded. These recordings were used to measure FI postoperatively using OsiriX imaging software. Serum CRP, I-FABP, and calprotectin values were determined before surgery and on day 1, 3, and 5 postoperative; furthermore, the occurrence of AL was recorded.

resultsThirty patients (n = 19 males; mean age 67 years; mean BMI 27.2) undergoing either laparoscopic or robotic anastomotic colorectal surgery were included. Indication for surgery was rectal-(n = 10), rectosigmoid-(n = 2), sigmoid-(n = 10), or more proximal colon carcinomas (n = 8). Five patients (16.7%) developed AL (n = 2 (6.6%) grade C according to the definition of the International Study group of Rectal Cancer). In patients with AL, the maximum fluorescence score was given less often (P = 0.02) and a lower FI compared to background FI was measured at 1st assessment (P = 0.039). However, no relation between FI and postoperative inflammatory parameters could be found.

conclusionBoth subjective and measured FI seem to be related to AL. In this study, no relation between FI and inflammatory serum markers could yet be found.

Indexed as

Spectroscopy, Near-InfraredAgedAnastomosis, SurgicalAnastomotic LeakBiomarkersColorectal NeoplasmsC-Reactive ProteinFemaleHumansLaparoscopyMaleMiddle AgedPilot ProjectsPostoperative PeriodProspective StudiesRectal NeoplasmsBiomarkersC-Reactive ProteinAnastomotic leakageCalprotectinColorectal cancer surgeryCRPI-FABPNear-infrared fluorescenceNIRF

Identifiers

PMID30710314
PMCPMC6795629
OpenAlexW2911606272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.