Evidence map›Paper›PMID 30710281›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2019

Targeting S100 Calcium-Binding Proteins with Small Molecule Inhibitors.

Paul T Wilder, Kristen M Varney, David J Weber

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Paul T WilderCenter for Biomolecular Therapeutics (CBT), Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.
Kristen M VarneyCenter for Biomolecular Therapeutics (CBT), Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.
David J WeberCenter for Biomolecular Therapeutics (CBT), Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA. dweber@som.umaryland.edu.
University of Maryland, Baltimore · USUniversity of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center

Funding

Restoration of Tumor Suppression Activity in Malignant MelanomaR01CA107331 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI WEBER, DAVID JOSEPH · 2006 to 2015
$5.4M
The Structure and Function of S100 ProteinsR01GM058888 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI WEBER, DAVID JOSEPH · 1999 to 2010
$3.4M
NCI NIH HHS R01 CA107331NIGMS NIH HHS R01 GM058888
6 · The paper itself

Abstract

S100B is a small, dimeric, calcium-binding protein that is implicated in various diseases, most significantly cancer; therefore, there is interest in identifying S100B inhibitors that may have therapeutic value (Bresnick et al. Nat Rev Cancer 15:96-109, 2015; Chong et al. Curr Med Chem 23:1571-1596). Two fluorescence polarization competition assays (FPCA) are described here for S100B and S100A1 that are amenable to high-throughput screening (HTS) campaigns and can be used to determine the binding affinity (K

Indexed as

AnimalsBinding SitesCattleHigh-Throughput Screening AssaysHumansModels, MolecularProtein BindingRatsS100 Calcium Binding Protein beta SubunitS100 ProteinsSmall Molecule LibrariesS100A1 proteinS100B protein, humanS100 Calcium Binding Protein beta SubunitS100 ProteinsSmall Molecule LibrariesCalcium bindingCancerFluorescence polarization competition assayHigh-throughput screeningInhibitorsMelanomaProtein-protein interfaceS100A1S100BS100 proteinSmall molecule

Identifiers

PMID30710281
PMCPMC7255693
OpenAlexW2912794045

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.