Evidence map›Paper›PMID 30710270›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2019

Designing Calcium-Binding Proteins for Molecular MR Imaging.

Mani Salarian, Shenghui Xue, Oluwatosin Y Ibhagui, Jenny J Yang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mani SalarianDepartment of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA, USA.
Shenghui XueDepartment of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA, USA.
Oluwatosin Y IbhaguiDepartment of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA, USA.
Jenny J YangDepartment of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA, USA. jenny@gsu.edu.
Georgia State University · USGreenLight Biosciences (United States) · US

Funding

Designing Magnetic Resonance Protein-based Contrast Agents with High RelaxivityR01EB007268 · NIBIB · GEORGIA STATE UNIVERSITY · PI YANG, JENNY J. · 2007 to 2015
$3.1M
Noninvasive Contrast Enhanced Early Detection of Melanoma Liver MetastasisR42CA183376 · NCI · INLIGHTA BIOSCIENCES, LLC · PI YANG, JENNY J. · 2017 to 2019
$2.0M
Detection and Staging of Liver Fibrosis by Precise MRI (pMRI)R42AA025863 · NIAAA · INLIGHTA BIOSCIENCES, LLC · PI YANG, JENNY J. · 2018 to 2020
$2.0M
Structural Biology of receptor-mediated extracellular calcium signalingR01GM081749 · NIGMS · GEORGIA STATE UNIVERSITY · PI YANG, JENNY J. · 2007 to 2011
$1.2M
NCI NIH HHS R42 CA183376NIAAA NIH HHS R42 AA025863NIBIB NIH HHS R01 EB007268NIGMS NIH HHS R01 GM081749
6 · The paper itself

Abstract

Early diagnosis, noninvasive detection, and staging of various diseases, remain one of the major clinical barriers to effective medical treatment and prevention of disease progression toward major clinical consequences. Molecular imaging technologies play an indispensable role in the clinical field in overcoming these major barriers. The increasing application of imaging techniques and agents in early detection of different diseases such as cancer has resulted in improved treatment response and clinical patient management. In this chapter we will first introduce criteria for the design and engineering of calcium-binding protein (CaBP) parvalbumin as a protein Gd-MRI contrast agent (ProCA) with unprecedented metal selectivity for Gd

Indexed as

AnimalsCalciumCell Line, TumorContrast MediaEarly Detection of CancerGadoliniumHumansKallikreinsMagnetic Resonance ImagingMaleMiceModels, MolecularMolecular ConformationMolecular ImagingNeoplasm TransplantationParvalbuminsCalciumContrast MediaGadoliniumKallikreinsKLK3 protein, humanParvalbuminsProstate-Specific AntigenCaBPContrast agentMolecular imagingMRIParvalbuminProCAPSMA

Identifiers

PMID30710270
PMCPMC6542288
OpenAlexW2914025236

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.