ArticleNature communications2019
Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- A systematic review and meta-analysis on the transcriptomic signatures in alcohol use disorder.Molecular psychiatry · 2025Pooled it
- Toward dissection of diverse neural components in the suprachiasmatic nucleus (SCN) pacemaker network.Neurobiology of sleep and circadian rhythms · 2026Article
- An Automated Organotypic SCN Culture System Revealing Novel Insights into VIP Regulation of Circadian Rhythm.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Neuronal feedback loop of the suprachiasmatic nucleus generates robust circadian rhythms.Nature communications · 2026Article
- Suprachiasmatic Nucleus Vasoactive Intestinal Peptide Neurons Mediate Light-induced Transient Forgetting.Neuroscience bulletin · 2025Article
- The Protective Role of DUSP4 in Retinal Pigment Epithelium Senescence and Degeneration.International journal of molecular sciences · 2025Article
- The vertebrate segmentation clock drives segmentation by stabilizing Dusp phosphatases in zebrafish.Developmental cell · 2025Article
- Neuropeptidergic Input from the Lateral Hypothalamus to the Suprachiasmatic Nucleus Alters the Circadian Period in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Beyond vision: effects of light on the circadian clock and mood-related behaviours.Npj biological timing and sleep · 2025Review
- Loss of Bmal1 impairs the glutamatergic light input to the SCN in mice.Frontiers in cellular neuroscience · 2025Article
- Transcriptomic Plasticity of the Circadian Clock in Response to Photoperiod: A Study in Male Melatonin-Competent Mice.Journal of biological rhythms · 2024Article
- Adaptive Differences in Cellular and Behavioral Responses to Circadian Disruption between C57BL/6 and BALB/c Strains.International journal of molecular sciences · 2024Article
- On the origin and evolution of the dual oscillator model underlying the photoperiodic clockwork in the suprachiasmatic nucleus.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- Diabetes Reshapes the Circadian Transcriptome Profile in Murine Retina.Investigative ophthalmology & visual science · 2023Article
- Circadian Rhythms and Astrocytes: The Good, the Bad, and the Ugly.Annual review of neuroscience · 2023Review
- The multiple roles of salt-inducible kinases in regulating physiology.Physiological reviews · 2023Review
- Astrocytic control of extracellular GABA drives circadian timekeeping in the suprachiasmatic nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The Mammalian Circadian Time-Keeping System.Journal of Huntington's disease · 2023Review
- Article
- Sexual dimorphism in the bed nucleus of the stria terminalis, medial preoptic area and suprachiasmatic nucleus in male and female tree shrews.Journal of anatomy · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
The suprachiasmatic nucleus (SCN) co-ordinates circadian behaviour and physiology in mammals. Its cell-autonomous circadian oscillations pivot around a well characterised transcriptional/translational feedback loop (TTFL), whilst the SCN circuit as a whole is synchronised to solar time by its retinorecipient cells that express and release vasoactive intestinal peptide (VIP). The cell-autonomous and circuit-level mechanisms whereby VIP synchronises the SCN are poorly understood. We show that SCN slices in organotypic culture demonstrate rapid and sustained circuit-level circadian responses to VIP that are mediated at a cell-autonomous level. This is accompanied by changes across a broad transcriptional network and by significant VIP-directed plasticity in the internal phasing of the cell-autonomous TTFL. Signalling via ERK1/2 and tuning by its negative regulator DUSP4 are critical elements of the VIP-directed circadian re-programming. In summary, we provide detailed mechanistic insight into VIP signal transduction in the SCN at the level of genes, cells and neural circuit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.