Evidence map›Paper›PMID 30710063›Full record

ArticleBioscience reports2019

Plasma lipidomic profiling in murine mutants of Hermansky-Pudlak syndrome reveals differential changes in pro- and anti-atherosclerotic lipids.

Jing Ma, Raoxu Wang, Sin Man Lam, Chang Zhang, Guanghou Shui, Wei Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Jing MaBeijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute; Genetics and Birth Defects Control Center, National Center for Children's Health; MOE Key Laboratory of Major Diseases in Children; Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
Raoxu WangInstitute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
Sin Man LamInstitute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
Chang ZhangInstitute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
Guanghou ShuiInstitute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China ghshui@genetics.ac.cn liwei@bch.com.cn.
Wei LiBeijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute; Genetics and Birth Defects Control Center, National Center for Children's Health; MOE Key Laboratory of Major Diseases in Children; Beijing Children's Hospital, Capital Medical University, Beijing 100045, China ghshui@genetics.ac.cn liwei@bch.com.cn.ORCID 0000-0001-7430-6019
Chinese Academy of Sciences · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis is characterized by the accumulation of lipid-rich plaques in the arterial wall. Its pathogenesis is very complicated and has not yet been fully elucidated. It is known that dyslipidemia is a major factor in atherosclerosis. Several different Hermansky-Pudlak syndrome (HPS) mutant mice have been shown either anti-atherosclerotic or atherogenic phenotypes, which may be mainly attributed to corresponding lipid perturbation. To explore the effects of different HPS proteins on lipid metabolism and plasma lipid composition, we analyzed the plasma lipid profiles of three HPS mutant mice,

Indexed as

AnimalsAtherosclerosisDisease Models, AnimalGene DeletionHermanski-Pudlak SyndromeIntracellular Signaling Peptides and ProteinsLipid MetabolismLipidomicsLipidsMaleMembrane ProteinsMiceMice, Inbred C57BLBloc1s6 protein, mouseHps1 protein, mouseHps6 protein, mouseIntracellular Signaling Peptides and ProteinsLipidsMembrane ProteinsatherosclerosisHermansky-Pudlak syndromelipid metabolismlipidomicsvesicle trafficking

Identifiers

PMID30710063
PMCPMC6379572
OpenAlexW2912013308

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.