Evidence map›Paper›PMID 30709959›Full record

ArticleThe Journal of rheumatology2019

Predictors of Hand Contracture in Early Systemic Sclerosis and the Effect on Function: A Prospective Study of the GENISOS Cohort.

Maryam Buni, Joyce Joseph, Claudia Pedroza, Sam Theodore, Deepthi Nair, Terry A McNearney, Hilda T Draeger, John D Reveille, Shervin Assassi, Maureen D Mayes

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of rheumatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Maryam BuniFrom the Department of Internal Medicine, Center for Clinical Research and Evidence-Based Medicine, and Department of Pediatrics, University of Texas McGovern Medical School, Houston, Texas, USA.
Joyce JosephFrom the Department of Internal Medicine, Center for Clinical Research and Evidence-Based Medicine, and Department of Pediatrics, University of Texas McGovern Medical School, Houston, Texas, USA.
Claudia PedrozaFrom the Department of Internal Medicine, Center for Clinical Research and Evidence-Based Medicine, and Department of Pediatrics, University of Texas McGovern Medical School, Houston, Texas, USA.
Sam TheodoreFrom the Department of Internal Medicine, Center for Clinical Research and Evidence-Based Medicine, and Department of Pediatrics, University of Texas McGovern Medical School, Houston, Texas, USA.
Deepthi NairFrom the Department of Internal Medicine, Center for Clinical Research and Evidence-Based Medicine, and Department of Pediatrics, University of Texas McGovern Medical School, Houston, Texas, USA.
Terry A McNearneyFrom the Department of Internal Medicine, Center for Clinical Research and Evidence-Based Medicine, and Department of Pediatrics, University of Texas McGovern Medical School, Houston, Texas, USA.
Hilda T DraegerFrom the Department of Internal Medicine, Center for Clinical Research and Evidence-Based Medicine, and Department of Pediatrics, University of Texas McGovern Medical School, Houston, Texas, USA.
John D ReveilleFrom the Department of Internal Medicine, Center for Clinical Research and Evidence-Based Medicine, and Department of Pediatrics, University of Texas McGovern Medical School, Houston, Texas, USA.
Shervin AssassiFrom the Department of Internal Medicine, Center for Clinical Research and Evidence-Based Medicine, and Department of Pediatrics, University of Texas McGovern Medical School, Houston, Texas, USA.
Maureen D MayesFrom the Department of Internal Medicine, Center for Clinical Research and Evidence-Based Medicine, and Department of Pediatrics, University of Texas McGovern Medical School, Houston, Texas, USA. Maureen.d.mayes@uth.tmc.edu.
Medical Care Development International · US

Funding

U OF TEXAS HLTH SCI CTR HOUSTON CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCESUL1RR024148 · NCRR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2006 to 2010
$27.9M
Center for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4M
Role of TGF-beta and CTGF Signaling Transgenic Mouse Models of SclerodermaP50AR054144 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARNETT, FRANK C · 2006 to 2010
$7.7M
Two-Stage Genome-Wide Association Study in Systemic SclerosisR01AR055258 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MAYES, MAUREEN MAUREEN · 2008 to 2012
$5.9M
Institutional Career Development CoreKL2TR003168 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MILLER, CHARLES C · 2019 to 2023
$4.9M
SCLERODERMA FAMILY REGISTRY AND DNA REPOSITORY-264002251-264002251-264002251N01AR002251 · NIAMS · WAYNE STATE UNIVERSITY · PI MAYES, MAUREEN · 2000 to 2006
$659k
Molecular Markers for Progression of Pulmonary Fibrosis in Systemic SclerosisK23AR061436 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ASSASSI, SHERVIN · 2011 to 2014
$494k
NCATS NIH HHS KL2 TR003168NCATS NIH HHS UL1 TR000371NCRR NIH HHS UL1 RR024148NIAMS NIH HHS K23 AR061436NIAMS NIH HHS N01 AR002251NIAMS NIH HHS P50 AR054144NIAMS NIH HHS R01 AR055258
6 · The paper itself

Abstract

objectiveTo identify baseline features that predict progression of hand contractures and to assess the effect of contractures on functional status in the prospective GENISOS cohort.

methodsRate of decline in hand extension, as an indicator of hand contracture, was the primary outcome. We assessed longitudinal hand extension measurements, modified Health Assessment Questionnaire (MHAQ) score, Medical Outcomes Study Short Form-36 (SF-36) physical function score, and demographic, clinical, and serological variables. Subjects with ≥ 2 hand measurements at least 6 months apart were included.

resultsA total of 1087 hand measurements for 219 patients were available over an average of 8.1 ± 4.8 years. Hand extension decreased on average by 0.11 cm/year. Antitopoisomerase I antibody (ATA) positivity and higher modified Rodnan Skin Score (mRSS) were predictive of faster decline in hand extension (p = 0.009 and p = 0.046, respectively). In a subgroup analysis of 62 patients with ≤ 2 years from SSc onset, ATA and diffuse disease type were associated with faster decline in hand extension; anticentromere positivity was associated with slower rate of decline. Although the rate of decline in patients with disease duration ≤ 2 years was numerically higher, the difference was not statistically significant. Hand extension continued to decline in a linear fashion over time and was inversely related to overall functional status.

conclusionATA was predictive of contracture development in both early disease (≤ 2 yrs) and in the overall cohort. Hand extension declined linearly over time and was inversely associated with MHAQ and SF-36 scores. ATA positivity and higher baseline mRSS were predictive of faster decline in hand extension.

Indexed as

AdultContractureDisease ProgressionFemaleHandHumansMaleMiddle AgedPrognosisProspective StudiesRisk FactorsScleroderma, SystemicSeverity of Illness IndexHAND CONTRACTUREHAND FUNCTIONSYSTEMIC SCLEROSIS

Identifiers

PMID30709959
PMCPMC6675665
OpenAlexW2914282246

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.