ArticleCancer research2019
Transcriptome-Wide Association Study Identifies New Candidate Susceptibility Genes for Glioma.
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Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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23citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
What it found
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Brain multi-omic Mendelian randomisation to identify novel drug targets for gliomagenesis.Human molecular genetics · 2025Pooled it
- Single-cell multi-omic integration analysis prioritizes druggable genes and reveals cell-type-specific causal effects in glioblastomagenesis.Journal of translational medicine · 2026Article
- Imaging-mediated genetic effects link brain microstructure, metabolic profiles, and regional transcription to glioma susceptibility.Frontiers in immunology · 2026Article
- Deciphering genetic susceptibility to clear cell renal cell carcinoma.Communications biology · 2025Article
- The G Protein-Coupled Receptor-Related Gene Signatures for Diagnosis and Prognosis in Glioblastoma: A Deep Learning Model Using RNA-Seq Data.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Identification of Brain Cell Type-Specific Therapeutic Targets for Glioma From Genetics.CNS neuroscience & therapeutics · 2024Article
- A statistical method for image-mediated association studies discovers genes and pathways associated with four brain disorders.American journal of human genetics · 2024Article
- The construction of a novel prognostic prediction model for glioma based on GWAS-identified prognostic-related risk loci.Open medicine (Warsaw, Poland) · 2024Article
- Transcriptomic and connectomic correlates of differential spatial patterning among gliomas.Brain : a journal of neurology · 2023Article
- Molecular landscapes of glioblastoma cell lines revealed a group of patients that do not benefit fromFrontiers in neuroscience · 2023Article
- Delivering the Promise of Gene Therapy with Nanomedicines in Treating Central Nervous System Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Early-Stage Loss of GALNT6 Predicts Poor Clinical Outcome in Colorectal Cancer.Frontiers in oncology · 2022Article
- Comprehensive Analysis of a Ferroptosis Pattern and Associated Prognostic Signature in Acute Myeloid Leukemia.Frontiers in pharmacology · 2022Article
- Integrating genome-wide association and transcriptome prediction model identifies novel target genes for osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- A Genome-Wide Profiling of Glioma Patients with an IDH1 Mutation Using the Catalogue of Somatic Mutations in Cancer Database.Cancers · 2021Article
- Pleiotropy-guided transcriptome imputation from normal and tumor tissues identifies candidate susceptibility genes for breast and ovarian cancer.HGG advances · 2021Article
- Functional analysis of low-grade glioma genetic variants predicts key target genes and transcription factors.Neuro-oncology · 2021Article
- Power analysis of transcriptome-wide association study: Implications for practical protocol choice.PLoS genetics · 2021Article
- CoMM-SFrontiers in genetics · 2021Article
- Meta-Analyses of Splicing and Expression Quantitative Trait Loci Identified Susceptibility Genes of Glioma.Frontiers in genetics · 2021Article
Corrections and comments
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Authors and funding
28 authors at 20 institutions in 8 countries.
Isabelle Atkins *Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.
Ben Kinnersley *Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom. ben.kinnersely@icr.ac.uk.
Quinn T OstromCase Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio.ORCID 0000-0003-3469-7558
Karim LabrecheDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.
Dora Il'yasovaDepartment of Population Health Sciences, School of Public Health, Georgia State University, Atlanta, Georgia.ORCID 0000-0003-4290-6794
Georgina N ArmstrongDepartment of Medicine, Section of Epidemiology and Population Sciences, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
Jeanette E Eckel-PassowDivision of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, Minnesota.
Minouk J SchoemakerDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.ORCID 0000-0001-8403-2234
Markus M NöthenDepartment of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
Jill S Barnholtz-SloanCase Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio.
Anthony J SwerdlowDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.ORCID 0000-0001-5550-4159
Matthias SimonDepartment of Neurosurgery, University of Bonn Medical Center, Bonn, Germany.
Preetha RajaramanDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Joellen ShildkrautDepartment of Public Health Sciences, University of Virginia, Charlottesville, Virginia.
Jonine L BernsteinDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
Per HoffmannDepartment of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
Karl-Heinz JöckelInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Rose K LaiDepartments of Neurology and Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Elizabeth B ClausSchool of Public Health, Yale University, New Haven, Connecticut.
Sara H OlsonDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
Christoffer JohansenInstitute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.
Margaret R WrenschDepartment of Neurological Surgery, School of Medicine, University of California, San Francisco, San Francisco, California.
Beatrice MelinDepartment of Radiation Sciences, Umeå University, Umeå, Sweden.
Robert B JenkinsDepartment of Laboratory Medicine and Pathology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Rochester, Minnesota.
Marc SansonSorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM, Paris, France.
Melissa L BondyDepartment of Medicine, Section of Epidemiology and Population Sciences, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
Richard S HoulstonDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.ORCID 0000-0002-5268-0242
Cancer Research UK · GBBaylor College of Medicine · USCancer Genetics (United States) · USMayo Clinic · USMemorial Sloan Kettering Cancer Center · USBreast Cancer Now · GBBrigham and Women's Hospital · USCase Western Reserve University · USCentre National de la Recherche Scientifique · FRDepartment of Biomedicine Basel · CHDuke University · USEssen University Hospital · DEInstitute of Cancer Research · GBUmeå University · SEUniversity Hospital Bonn · DEUniversity of Bonn · DEUniversity of California, San Francisco · USUniversity of Copenhagen · DKUniversity of Southern California · USUniversity of Virginia · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MTumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9MGENETIC EPIDEMIOLOGY OF MALIGNANT GLIOMAR01CA052689 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K., WRENSCH, MARGARET R. · 1991 to 2015
$20.5MInternational Case Control Study of Malignant GliomaR01CA139020 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BONDY, MELISSA L. · 2010 to 2015
$16.0MGenetic Epidemiology of Glioma International ConsortiumR01CA119215 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BONDY, MELISSA L. · 2006 to 2010
$11.9MCancer Research UK A8362NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA125123NCI NIH HHS R01 CA052689NCI NIH HHS R01 CA119215NCI NIH HHS R01 CA139020Wellcome Trust
Abstract
Genome-wide association studies (GWAS) have so far identified 25 loci associated with glioma risk, with most showing specificity for either glioblastoma (GBM) or non-GBM tumors. The majority of these GWAS susceptibility variants reside in noncoding regions and the causal genes underlying the associations are largely unknown. Here we performed a transcriptome-wide association study to search for novel risk loci and candidate causal genes at known GWAS loci using Genotype-Tissue Expression Project (GTEx) data to predict
Indexed as
Genetic Predisposition to DiseasePolymorphism, Single NucleotideTranscriptomeBiomarkers, TumorCase-Control StudiesGene Expression Regulation, NeoplasticGenome-Wide Association StudyGenotypeGliomaHumansPrognosisQuantitative Trait LociBiomarkers, Tumor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.