Evidence map›Paper›PMID 30709904›Full record

ArticleThe Journal of biological chemistry2019

MicroRNA-144-3p targets relaxin/insulin-like family peptide receptor 1 (RXFP1) expression in lung fibroblasts from patients with idiopathic pulmonary fibrosis.

Harinath Bahudhanapati, Jiangning Tan, Justin A Dutta, Stephen B Strock, John Sembrat, Diana Àlvarez, Mauricio Rojas, Benedikt Jäger, Antje Prasse, Yingze Zhang and 1 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
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  3. Phylogenetic Relations and High-Altitude Adaptation in Wild Boar (Animals : an open access journal from MDPI · 2024
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  12. Dopamine Receptor D1 Is Exempt from Transforming Growth FactorThe Journal of pharmacology and experimental therapeutics · 2023
    Article
  13. miR-29a-3p Regulates Autophagy by Targeting Akt3-Mediated mTOR in SiOInternational journal of molecular sciences · 2023
    Article
  14. Review
  15. Article
  16. Article
  17. Genetic Delivery and Gene Therapy in Pulmonary Hypertension.International journal of molecular sciences · 2021
    Review
  18. Article
  19. Article
  20. More than a Genetic Code: Epigenetics of Lung Fibrosis.Molecular diagnosis & therapy · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Harinath BahudhanapatiFrom the Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Jiangning TanFrom the Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Justin A DuttaFrom the Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.ORCID 0000-0002-1740-0639
Stephen B StrockFrom the Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
John SembratFrom the Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Diana ÀlvarezFrom the Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Mauricio RojasFrom the Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Benedikt JägerFraunhofer ITEM, Deutsches Zentrum für Lungenforschung (DZL) BREATH, Nicolai-Fuchs-Straße 1, 30625 Hannover, Germany.
Antje PrasseFraunhofer ITEM, Deutsches Zentrum für Lungenforschung (DZL) BREATH, Nicolai-Fuchs-Straße 1, 30625 Hannover, Germany.
Yingze ZhangFrom the Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Daniel J KassFrom the Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, kassd2@upmc.edu.ORCID 0000-0001-6597-7830
University of Pittsburgh · USFraunhofer Institute for Toxicology and Experimental Medicine · DEMedizinische Hochschule Hannover · DE

Funding

Translational studies for identifying and targeting novel pathways in systemic sclerosis pathogenesisP50AR060780 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LAFYATIS, ROBERT A. · 2011 to 2021
$14.9M
Aging of Mesenchymal Stem Cells Missing Link in IPFR01HL123766 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROJAS, MAURICIO · 2015 to 2018
$1.9M
Twist1 subphenotypes and pulmonary fibrosisR01HL126990 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KASS, DANIEL J · 2015 to 2019
$1.9M
NHLBI NIH HHS R01 HL123766NHLBI NIH HHS R01 HL126990NIAMS NIH HHS P50 AR060780
6 · The paper itself

Abstract

The hormone relaxin is considered a potential therapy for idiopathic pulmonary fibrosis (IPF). We have previously shown that a potential limitation to relaxin-based IPF therapy is decreased expression of a relaxin receptor, relaxin/insulin-like family peptide receptor 1 (RXFP1), in IPF fibroblasts. The mechanism that down-regulates RXFP1 in IPF remains unclear. To determine whether microRNAs (miRs) regulate

Indexed as

3' Untranslated RegionsCells, CulturedFibroblastsGene Expression RegulationHumansIdiopathic Pulmonary FibrosisLungMicroRNAsProto-Oncogene MasReceptors, G-Protein-CoupledReceptors, PeptideRNA, Messenger3' Untranslated RegionsMAS1 protein, humanMicroRNAsMIRN144 microRNA, humanProto-Oncogene MasReceptors, G-Protein-CoupledReceptors, PeptideRNA, MessengerRXFP1 protein, humanepigeneticsfibroblastidiopathic pulmonary fibrosislung diseaselung fibroblastsmicroRNA (miRNA)miR-144-3pmyofibroblastpost-transcriptional regulationpulmonary fibrosisrelaxinrelaxin/insulin-like family peptide receptor 1 (RXFP1)transforming growth factor β (TGF-B)

Identifiers

PMID30709904
PMCPMC6442041
OpenAlexW2914008351

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.