Evidence map›Paper›PMID 30709875›Full record

ReviewCold Spring Harbor molecular case studies2019

Hematologic malignancies and Li-Fraumeni syndrome.

Mahesh Swaminathan, Sarah A Bannon, Mark Routbort, Kiran Naqvi, Tapan M Kadia, Koichi Takahashi, Yesid Alvarado, Farhad Ravandi-Kashani, Keyur P Patel, Richard Champlin and 3 more

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cold Spring Harbor molecular case studies, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 79 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Genetic Predisposition to Hematologic Malignancies.Cold Spring Harbor perspectives in medicine · 2025
    Review
  9. Review
  10. Review
  11. Chronic myelogenous leukemia secondary to colon cancer: A case report.World journal of gastrointestinal oncology · 2025
    Article
  12. Review
  13. Review
  14. Clonal hematopoiesis and hematological malignancy.The Journal of clinical investigation · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Mahesh SwaminathanDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas 77005, USA.
Sarah A BannonDepartment of Clinical Cancer Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77005, USA.
Mark RoutbortDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77005, USA.
Kiran NaqviDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas 77005, USA.
Tapan M KadiaDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas 77005, USA.
Koichi TakahashiDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas 77005, USA.ORCID 0000-0002-8027-9659
Yesid AlvaradoDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas 77005, USA.
Farhad Ravandi-KashaniDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas 77005, USA.
Keyur P PatelDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77005, USA.
Richard ChamplinDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas 77005, USA.
Hagop KantarjianDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas 77005, USA.
Louise StrongDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77005, USA.
Courtney D DiNardoDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas 77005, USA.
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
University of Texas M.D. Anderson Cancer SPORE-LeukemiaP50CA100632 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SHPALL, ELIZABETH J · 2003 to 2023
$43.7M
NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA100632
6 · The paper itself

Abstract

Li-Fraumeni syndrome (LFS) is an autosomal dominant condition associated with a high risk of a broad range of childhood- and adult-onset cancers. LFS is related to germline mutations of the tumor-suppressor gene

Indexed as

Germ-Line MutationAdultFemaleGenetic Predisposition to DiseaseHematologic NeoplasmsHumansLeukemia, Myeloid, AcuteLi-Fraumeni SyndromeMaleMiddle AgedMyelodysplastic SyndromesPedigreeTumor Suppressor Protein p53Young AdultTumor Suppressor Protein p53leukemiamultiple lineage myelodysplasia

Identifiers

PMID30709875
PMCPMC6371746
OpenAlexW2914827658

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.