ArticleDisease models & mechanisms2019
Serotonin inhibits axonal regeneration of identifiable descending neurons after a complete spinal cord injury in lampreys.
Article in Disease models & mechanisms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Article
- Organization of Serotonergic Cell Populations in the Brain and Spinal Cord of the Short-Lived African Turquoise Killifish.Biology · 2025Article
- Spontaneous regeneration of cholecystokinergic reticulospinal axons after a complete spinal cord injury in sea lampreys.Computational and structural biotechnology journal · 2024Article
- Spinal cord injury significantly alters the properties of reticulospinal neurons: delayed repolarization mediated by potassium channels.Journal of neurophysiology · 2023Article
- Morpholino studies shed light on the signaling pathways regulating axon regeneration in lampreys.Neural regeneration research · 2022Article
- Full regeneration of descending corticotropin-releasing hormone axons after a complete spinal cord injury in lampreys.Computational and structural biotechnology journal · 2022Article
- Serotonin transporter-mediated molecular axis regulates regional retinal ganglion cell vulnerability and axon regeneration after nerve injury.PLoS genetics · 2021Article
- Distribution of two isoforms of tryptophan hydroxylase in the brain of rainbow trout (Oncorhynchus mykiss). An in situ hybridization study.Brain structure & function · 2021Article
- Survival and Axonal Outgrowth of the Mauthner Cell Following Spinal Cord Crush Does Not Drive Post-injury Startle Responses.Frontiers in cell and developmental biology · 2021Article
- Citalopram Administration Does Not Promote Function or Histological Recovery after Spinal Cord Injury.International journal of molecular sciences · 2020Article
- PTPσ Knockdown in Lampreys Impairs Reticulospinal Axon Regeneration and Neuronal Survival After Spinal Cord Injury.Frontiers in cellular neuroscience · 2020Article
- Data on the effect of a muscimol treatment in caspase activation in descending neurons of lampreys after a complete spinal cord injury.Data in brief · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Classical neurotransmitters are mainly known for their roles as neuromodulators, but they also play important roles in the control of developmental and regenerative processes. Here, we used the lamprey model of spinal cord injury to study the effect of serotonin in axon regeneration at the level of individually identifiable descending neurons. Pharmacological and genetic manipulations after a complete spinal cord injury showed that endogenous serotonin inhibits axonal regeneration in identifiable descending neurons through the activation of serotonin 1A receptors and a subsequent decrease in cyclic adenosine monophosphate (cAMP) levels. RNA sequencing revealed that changes in the expression of genes that control axonal guidance could be a key factor determining the serotonin effects during regeneration. This study provides new targets of interest for research in non-regenerating mammalian models of traumatic central nervous system injuries and extends the known roles of serotonin signalling during neuronal regeneration. This article has an associated First Person interview with the first author of the paper.
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