Evidence map›Paper›PMID 30709652›Full record

ArticleBioorganic & medicinal chemistry letters2019

Radiosynthesis and evaluation of [

Jaya Prabhakaran, Kiran Kumar Solingapuram Sai, Anirudh Sattiraju, Akiva Mintz, J John Mann, J S Dileep Kumar

Open access · greenAbstract read
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Evaluation of [ACS chemical neuroscience · 2025
    Article
  3. Radiosynthesis and Evaluation ofACS pharmacology & translational science · 2025
    Article
  4. Article
  5. Radiosynthesis and evaluation of a novelAmerican journal of nuclear medicine and molecular imaging · 2024
    Article
  6. Development and Optimization ofACS pharmacology & translational science · 2023
    Review
  7. Article
  8. PET imaging of glycogen synthase kinase-3 in pancreatic cancer xenograft mouse models.American journal of nuclear medicine and molecular imaging · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jaya PrabhakaranMolecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, USA; Department of Psychiatry, Columbia University Medical Center, New York, USA. Electronic address: jaya.prabhakaran@nyspi.columbia.edu.
Kiran Kumar Solingapuram SaiDepartment of Radiology, Wake Forest School of Medicine, Winston Salem, NC, USA.
Anirudh SattirajuDepartment of Radiology, Columbia University Medical Center, New York, USA.
Akiva MintzDepartment of Radiology, Columbia University Medical Center, New York, USA.
J John MannMolecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, USA; Department of Psychiatry, Columbia University Medical Center, New York, USA; Department of Radiology, Columbia University Medical Center, New York, USA.
J S Dileep KumarMolecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, USA.
New York State Psychiatric InstituteColumbia University Irving Medical Center · USWake Forest University · US

Funding

Development of GSK-3beta PET radioligands for in vivo imaging in brainR21MH112037 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI PRABHAKARAN, JAYA · 2016 to 2017
$452k
NIMH NIH HHS R21 MH112037
6 · The paper itself

Abstract

Dysfunction of GSK3 is implicated in the etiology of many brain, inflammatory, cardiac diseases, and cancer. PET imaging would enable in vivo detection and quantification of GSK3 and can impact the choice of therapy, allow non-invasive monitoring of disease progression and treatment effects. In this report, the synthesis and evaluation of a high affinity GSK3 ligand, [

Indexed as

AnimalsATP Binding Cassette Transporter, Subfamily B, Member 1Blood-Brain BarrierCarbon RadioisotopesCell Line, TumorCyclosporineGlycogen Synthase Kinase 3HumansIsotope LabelingLigandsMaleNiacinamidePositron-Emission TomographyRadiopharmaceuticalsRats, Sprague-DawleyATP Binding Cassette Transporter, Subfamily B, Member 1Carbon-11Carbon RadioisotopesCyclosporineGlycogen Synthase Kinase 3LigandsNiacinamideRadiopharmaceuticalsBrainGSK3PETRadiotracer

Identifiers

PMID30709652
PMCPMC7703381
OpenAlexW2911880852

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.